美金刚未能“逆转”喹吡罗诱导的运动减少。
Failure of memantine to "reverse" quinpirole-induced hypomotility.
机构信息
Francesca Demontis, Gino Serra, Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
出版信息
World J Psychiatry. 2016 Jun 22;6(2):215-20. doi: 10.5498/wjp.v6.i2.215.
AIM
To evaluate antidepressant-like effect of memantine in a rat model.
METHODS
Male Wistar rats were treated intraperitoneally with either vehicle, memantine (10 mg/kg) or imipramine (20 mg/kg), for 3 wk. Twenty-four hour after the last treatment animals were challenged with quinpirole (0.3 mg/kg s.c.) and tested for motor activity. After 1 h habituation to the motility cages, the motor response was recorded for the following 45-min and the data were collected in 5-min time bins.
RESULTS
As expected, chronic treatment with imipramine potentiated the locomotor stimulant effect of quinpirole. On the contrary, chronic memantine administration failed to induce the behavioral supersensitivity to the dopamine agonist.
CONCLUSION
The results show that memantine, at variance with antidepressant treatments, fails to induce dopaminergic behavioral supersensitivity. This observation is consistent with the results of preclinical and clinical studies suggesting that memantine does not have an acute antidepressant action but does have an antimanic and mood-stabilizing effect.
目的
评估美金刚在大鼠模型中的抗抑郁样作用。
方法
雄性 Wistar 大鼠连续 3 周腹腔内给予载体、美金刚（10mg/kg）或丙咪嗪（20mg/kg）。末次给药后 24 小时，动物接受喹吡罗（0.3mg/kg，皮下）挑战，并进行运动活性测试。在适应活动笼 1 小时后，记录 45 分钟的运动反应，数据以 5 分钟时间间隔收集。
结果
如预期的那样，慢性丙咪嗪治疗增强了喹吡罗的促运动刺激作用。相反，慢性美金刚给药未能诱导对多巴胺激动剂的行为超敏反应。
结论
结果表明，美金刚与抗抑郁治疗不同，不能诱导多巴胺能行为超敏反应。这一观察结果与临床前和临床研究的结果一致，表明美金刚没有急性抗抑郁作用，但具有抗躁狂和稳定情绪的作用。
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