Tan Zhenda, Jiang Huanfeng, Zhang Min
School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, P. R. China.
Chem Commun (Camb). 2016 Aug 4;52(60):9359-62. doi: 10.1039/c6cc03996k. Epub 2016 Jun 29.
A novel iridium/acid co-catalysed transfer hydrogenative coupling strategy, enabling direct alkylation of C(sp(3))-H bonds and atom-economic access to alkyl chain-lengthened N-heteroaromatics from six-membered 2-alkyl cyclic amines and aldehydes, has been demonstrated. This work has built an important basis to convert cyclic amines, a class of bulk chemical raw materials, into functionalized products.
已证明一种新型铱/酸共催化的转移氢化偶联策略，该策略能够实现C(sp(3))-H键的直接烷基化，并通过六元2-烷基环胺和醛以原子经济的方式获得烷基链延长的氮杂芳烃。这项工作为将一类大宗化学原料环状胺转化为功能化产品奠定了重要基础。
