*Department of Surgery & Cancer, Imperial College London, London†St Mark's Hospital and Academic Institute, Harrow, UK.
Ann Surg. 2016 Nov;264(5):854-861. doi: 10.1097/SLA.0000000000001877.
(i) To establish at a national level clinical outcomes from patients presenting with acute para-esophageal hernia (PEH); and (ii) to determine if a hospital volume-outcome relationship exists for the management of acute PEH.
Currently, no clear guidelines exist regarding the management of acute PEH, and practice patterns are based upon relatively small case series.
Patients admitted as an emergency for the treatment of acute PEH between 1997 and 2012 were included from the Hospital Episode Statistics database. The influence of hospital volume upon clinical outcomes was analyzed in unmatched and matched comparisons to control for patient age, medical comorbidities, and incidence of PEH hernia gangrene.
Over the 16-year study period, 12,441 patients were admitted as an emergency with a PEH causing obstruction or gangrene. Of these, 90.8% patients were admitted with PEH with obstruction in the absence of gangrene and 9.2% with PEH with gangrene. The incidences of 30 and 90-day mortality were 7% and 11.5%, respectively, which did not decrease during the study period. Unmatched and matched comparisons showed, in high-volume centers, there were significant reductions in utilization of emergency surgery (8.8% vs 14.9%; P < 0.0001), 30-day (5.3% vs 7.8%; P < 0.0001), and 90-day mortality (9.3% vs 12.7%; P < 0.0001). Multivariate analysis also confirmed high hospital volume was independently associated with reduced 30 and 90-day mortality from acute PEH.
Acute PEH represents a highly morbid condition, and treatment in high-volume centers provides the appropriate multidisciplinary infrastructure to manage these complex patients reducing associated mortality.
(i)在国家层面上确定患有急性食管旁疝(PEH)的患者的临床结局;(ii)确定管理急性 PEH 是否存在医院量效关系。
目前,对于急性 PEH 的管理尚无明确的指南,实践模式是基于相对较小的病例系列。
从医院入院统计数据库中纳入 1997 年至 2012 年间因急性 PEH 紧急入院的患者。在不匹配和匹配的比较中,分析了医院量对临床结局的影响,以控制患者年龄、合并症和 PEH 疝坏疽的发生率。
在 16 年的研究期间,有 12441 名患者因 PEH 引起的梗阻或坏疽而紧急入院。其中,90.8%的患者因无坏疽的 PEH 梗阻入院,9.2%的患者因 PEH 坏疽入院。30 天和 90 天的死亡率分别为 7%和 11.5%,在研究期间没有下降。不匹配和匹配的比较表明,在高容量中心,急诊手术的使用率(8.8%比 14.9%;P<0.0001)、30 天(5.3%比 7.8%;P<0.0001)和 90 天死亡率(9.3%比 12.7%;P<0.0001)均显著降低。多变量分析也证实,高医院量与急性 PEH 的 30 天和 90 天死亡率降低独立相关。
急性 PEH 是一种高度病态的疾病,在高容量中心治疗可为管理这些复杂患者提供适当的多学科基础设施,从而降低相关死亡率。