Malmkvist G
Department of Anesthesiology, University Hospital, Lund, Sweden.
Anesth Analg. 1989 Jun;68(6):763-6.
The aim of this study was to evaluate the effect on oxygenation of intermittent inflation with oxygen of the collapsed lung during one-lung ventilation (OLV). Sixteen patients were studied during pulmonary surgery. Balanced anesthesia with nitrous oxide and an inspired oxygen fraction of 0.5 was used. The control group (N = 8) had a median PaO2 of 19.2 (range 11.2-30.2) kPa before OLV, and 10.2 (8.2-16.0) kPa after 9 minutes of OLV without further reduction in PaO2 for another 10 minutes. In the treatment (inflation) group, the collapsed lung was manually inflated with 2 liters of oxygen and was then immediately allowed to collapse again. This procedure was repeated every 5 minutes during OLV. PaO2 increased more than 4 kPa following each inflation in seven patients. In the eighth, PaO2 remained high throughout OLV. Although PaO2 decreased between inflations, it never reached the level observed in controls during 19 minutes of OLV.
本研究旨在评估单肺通气（OLV）期间对萎陷肺进行间歇性充氧对氧合的影响。对16例接受肺部手术的患者进行了研究。采用一氧化二氮和吸入氧分数为0.5的平衡麻醉。对照组（N = 8）在OLV前PaO₂中位数为19.2（范围11.2 - 30.2）kPa，OLV 9分钟后为10.2（8.2 - 16.0）kPa，且在接下来的10分钟内PaO₂未进一步降低。在治疗（充气）组中，用2升氧气手动对萎陷肺进行充气，然后立即使其再次萎陷。在OLV期间每5分钟重复此操作一次。7例患者每次充气后PaO₂升高超过4 kPa。第8例患者在整个OLV期间PaO₂保持在较高水平。尽管充气期间PaO₂有所下降，但在19分钟的OLV期间从未达到对照组所观察到的水平。
