使用芳基糖苷供体的DNA催化糖基化反应。
DNA-catalyzed glycosylation using aryl glycoside donors.
作者信息
Hesser Anthony R, Brandsen Benjamin M, Walsh Shannon M, Wang Puzhou, Silverman Scott K
机构信息
Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA.
出版信息
Chem Commun (Camb). 2016 Jul 28;52(59):9259-62. doi: 10.1039/c6cc04329a. Epub 2016 Jun 29.
Abstract
We report the identification by in vitro selection of Zn(2+)/Mn(2+)-dependent deoxyribozymes that glycosylate the 3'-OH of a DNA oligonucleotide. Both β and α anomers of aryl glycosides can be used as the glycosyl donors. Individual deoxyribozymes are each specific for a particular donor anomer.
摘要
我们报告了通过体外筛选鉴定出的锌（2+）/锰（2+）依赖性脱氧核酶，该酶可将寡核苷酸的3'-羟基糖基化。芳基糖苷的β和α异头物均可用作糖基供体。单个脱氧核酶对特定的供体异头物具有特异性。
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