2'-羧基苄基糖苷：用于C-糖基化及转化为其他糖基供体的糖基供体
2'-Carboxybenzyl glycosides: glycosyl donors for C-glycosylation and conversion into other glycosyl donors.
作者信息
Lee Yong Joo, Baek Ju Yuel, Lee Bo-Young, Kang Sung Soo, Park Hye-Seo, Jeon Heung Bae, Kim Kwan Soo
机构信息
Center for Bioactive Molecular Hybrids and Department of Chemistry, Yonsei University, Seoul 120-749, Republic of Korea.
出版信息
Carbohydr Res. 2006 Jul 24;341(10):1708-16. doi: 10.1016/j.carres.2006.03.014. Epub 2006 Apr 17.
Glycosylation of various glycosyl acceptors with 2'-carboxybenzyl (CB) 2,3,4,6-tetra-O-benzyl-beta-D-glucopyranoside and CB 2,3,4,6-tetra-O-benzyl-alpha-D-mannopyranoside as glycosyl donors afforded alpha-C-glycosides exclusively or predominantly in good yields. CB glycosides were also converted to other well-known glycosyl donors, the corresponding phenyl thioglycoside and the glycosyl fluoride derivatives.
以2'-羧基苄基（CB）2,3,4,6-四-O-苄基-β-D-吡喃葡萄糖苷和CB 2,3,4,6-四-O-苄基-α-D-吡喃甘露糖苷作为糖基供体，对各种糖基受体进行糖基化反应，可专一性地或主要以良好的产率得到α-C-糖苷。CB糖苷还可转化为其他知名的糖基供体，即相应的苯硫糖苷和糖基氟衍生物。
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