Exp Oncol. 2016 Jun;38(2):122-7.
The aim of the present study was to investigate the clinical and morphological features of nonspecific invasive breast cancer according to its molecular subtypes.
163 women with nonspecific invasive breast cancer (T1-4N0-3M0) were included in the present study. Luminal A type of breast cancer was detected in 101 women, luminal B type - in 23 women, overexpression of HER2/neu was identified in 14 women and triple-negative cancer - in 25 women.
The study revealed that various molecular subtypes of breast cancer differ in the morphological structure, the expression characteristics of the primary tumor and the rate of lymphogenous and hematogenous metastasis. Lymphogenous metastases were more frequently (in 71%) detected in HER2/neu overexpressing breast cancer than in luminal A (41%), luminal B (39%) and triple-negative tumors (40%). Hematogenous metastasis did not depend on the morphological structure of carcinoma infiltrative component, the state of tumor stroma as well as the proliferative activity in all the investigated groups.
The revealed clinicopathological characteristics of different molecular subtypes of invasive breast cancer allow to predict the possible outcome of the disease and select personalized treatment strategy for patients more reasonably.
本研究的目的是根据非特异性浸润性乳腺癌的分子亚型研究其临床和形态学特征。
本研究纳入了163例非特异性浸润性乳腺癌（T1-4N0-3M0）患者。其中101例为腔面A型乳腺癌，23例为腔面B型，14例检测到HER2/neu过表达，25例为三阴性乳腺癌。
研究表明，乳腺癌的不同分子亚型在形态结构、原发肿瘤的表达特征以及淋巴源性和血行转移率方面存在差异。HER2/neu过表达的乳腺癌中淋巴源性转移更为常见（71%），高于腔面A型（41%）、腔面B型（39%）和三阴性肿瘤（40%）。在所有研究组中，血行转移不依赖于癌浸润成分的形态结构、肿瘤间质状态以及增殖活性。
所揭示的浸润性乳腺癌不同分子亚型的临床病理特征有助于预测疾病的可能转归，并更合理地为患者选择个性化治疗策略。
