Wang J L, Chen Y D, Shi Y J, Xue H, Zhang W G, Gao L
Department of Cardiology, PLA General Hospital, Beijing 100853, China.
Zhonghua Yi Xue Za Zhi. 2016 Jun 21;96(23):1871-5. doi: 10.3760/cma.j.issn.0376-2491.2016.23.019.
To observe the variation of central hemodynamics and peripheral arterial stiffness in different ages and to investigate the parameters of differential effects in younger individuals (≤60y) and older individuals (>60y).
We conducted a population-based cross-sectional study in eight regions by random cluster sampling, from April to July 2014 in Beijing, China.Central hemodynamics and peripheral arterial stiffness parameters were determined in 861 healthy (372 male), normotensive individuals, aged 20 to 91(56±14) years.The main observed indexes were central systolic blood pressure (cSBP), arterial augmentation index (AI), augmentation pressure (AP), heart-ankle pulse wave velocity (haPWV) and brachial-ankle PWV (baPWV). Subjects were divided into six groups by 10 aged segment.Differences between groups and age tendency were observed.
The mean values of cSBP, AI, AP, haPWV and baPWV were (113±12) mmHg, (90±18)%, (-5±9) mmHg, (987±144) cm/s and (1 382±254) cm/s, respectively.cSBP, AI, AP, haPWV and baPWV increased with age (P<0.001). In average, cSBP, baPWV and haPWV increased 3 mmHg, 97 cm/s and 62 cm/s by additional 10 years, respectively.cSBP, AI and AP increased slowly after 60 years old, while haPWV and baPWV increased significantly with age (P<0.001). Stepwise regression analysis showed: cSBP was mainly relevant with mean arterial pressure(b=0.990, P<0.001), while baPWV and haPWV were relevant with age(b=8.858, 5.971; P<0.001). AI and AP were associated with height and rest heart rate (b=-0.676, -0.660 and b=-0.361, -0.341, P<0.001). Individuals were divided into two groups by age 60.The age-related changes in AI were significant in under 60-year-old; while the changes in baPWV were more prominent in over 60-year-old.However there was no significant difference in cSBP between two groups.
In healthy people, there are obvious differences of age tendency in central hemodynamics and peripheral arterial stiffness parameters.AI might be a good predictor of cardiovascular disease for early stage, especially for early coronary artery disease.
观察不同年龄段中心血流动力学及外周动脉僵硬度的变化，探讨青年个体（≤60岁）和老年个体（>60岁）差异效应的参数。
2014年4月至7月在中国北京，我们通过随机整群抽样在八个地区进行了一项基于人群的横断面研究。测定了861名健康（372名男性）、血压正常个体的中心血流动力学和外周动脉僵硬度参数，这些个体年龄在20至91岁（56±14岁）之间。主要观察指标为中心收缩压（cSBP）、动脉增强指数（AI）、增强压（AP）、心踝脉搏波速度（haPWV）和臂踝脉搏波速度（baPWV）。受试者按10岁年龄段分为六组。观察组间差异及年龄趋势。
cSBP、AI、AP、haPWV和baPWV的平均值分别为（113±12）mmHg、（90±18）%、（-5±9）mmHg、（987±144）cm/s和（1382±2）cm/s。cSBP、AI、AP、haPWV和baPWV随年龄增加（P<0.001）。平均而言，每增加10岁，cSBP、baPWV和haPWV分别增加3 mmHg、97 cm/s和62 cm/s。60岁后cSBP、AI和AP增加缓慢，而haPWV和baPWV随年龄显著增加（P<0.001）。逐步回归分析显示：cSBP主要与平均动脉压相关（b=0.990，P<0.001），而baPWV和haPWV与年龄相关（b=8.858，5.971；P<0.001）。AI和AP与身高和静息心率相关（b=-0.676，-0.660和b=-0.361，-0.341，P<0.001）。个体按60岁分为两组。60岁以下AI的年龄相关变化显著；而60岁以上baPWV的变化更明显。然而两组间cSBP无显著差异。
在健康人群中，中心血流动力学和外周动脉僵硬度参数的年龄趋势存在明显差异。AI可能是心血管疾病早期特别是早期冠状动脉疾病的良好预测指标。
