Center of Cardiology, Shanghai East Hospital, Tongji University, Jimo Road 150, Shanghai 200120, China.
Eur Heart J. 2010 Nov;31(22):2799-807. doi: 10.1093/eurheartj/ehq296. Epub 2010 Aug 26.
The brachial-ankle pulse wave velocity (baPWV) has been recognized as a marker that reflects arterial stiffness. We conducted an investigation to evaluate whether baPWV is independently associated with early mild diastolic heart failure (DHF) in a general middle and aged population.
From 1 July 2009 until 31 August 2009, we investigated 2095 subjects for the relevant factors of heart failure in the Lujiazui Community, Shanghai. The baPWV, echocardiography, and blood sampling were performed in the morning after a 12 h overnight fast. A total of 1929 subjects had the complete data, including questionnaire, age, gender, baPWV, brain natriuretic peptide, and E/A ratio. Early mild DHF was defined as a left ventricular ejection fraction >50%, E/A ratio <0.8, and E/E' ≤ 8; finally, 482 subjects with early mild DHF and 1282 subjects with non-DHF entered into analysis. Among 1764 subjects, 31.6% of the subjects were male (average age was 58.0 ± 12.3), 35.8% of the subjects had hypertension, the average body mass index (BMI) was 24.2 ± 3.3 kg/m(2), baPWV was 1513.0 (1329.1, 1763.5) cm/s, and the baPWV was significantly correlated with the E/A ratio (r = -0.39, P < 0.01). There was a difference of the baPWV [1456.0 (1295.3, 1698.3) vs. 1670.5 (1465.6, 1910.8) cm/s] between the non-DHF group and the early mild DHF group (P < 0.01). Multiple logistic-regression analyses demonstrated that age, male gender, BMI, baPWV, posterior left ventricular wall thickness (PVWT), interventricular septal thickness (IVST), E/E' ratio, left ventricular mass index (LVMI), systolic blood pressure (≥140 mmHg), and diastolic blood pressure (≥90 mmHg) were independently correlated with early mild DHF.
The increased arterial stiffness is associated with early mild DHF in a general middle and aged population independently of age, male gender, BMI, PVWT, IVST, E/E' ratio, LVMI, and high blood pressure. The non-invasive techniques described may allow serial measurements to be made over time to monitor baPWV changes in arteries provided the introduction of anti-arteriosclerosis therapy.
臂踝脉搏波速度（baPWV）已被认为是反映动脉僵硬度的标志物。我们进行了一项研究，以评估在一般中年人群中，baPWV 是否与早期轻度舒张性心力衰竭（DHF）独立相关。
2009 年 7 月 1 日至 2009 年 8 月 31 日，我们在上海陆家嘴社区调查了 2095 名与心力衰竭相关因素的受试者。受试者在禁食 12 小时的次日早晨进行了 baPWV、超声心动图和血液采样。共有 1929 名受试者具有完整的数据，包括问卷、年龄、性别、baPWV、脑钠肽和 E/A 比值。早期轻度 DHF 的定义为左心室射血分数>50%，E/A 比值<0.8，E/E'≤8；最终，482 名早期轻度 DHF 患者和 1282 名非 DHF 患者进入分析。在 1764 名受试者中，31.6%的受试者为男性（平均年龄为 58.0±12.3），35.8%的受试者患有高血压，平均体重指数（BMI）为 24.2±3.3kg/m2，baPWV 为 1513.0（1329.1，1763.5）cm/s，baPWV 与 E/A 比值显著相关（r=-0.39，P<0.01）。非 DHF 组和早期轻度 DHF 组的 baPWV[1456.0（1295.3，1698.3）vs.1670.5（1465.6，1910.8）cm/s]存在差异（P<0.01）。多因素逻辑回归分析表明，年龄、男性、BMI、baPWV、左心室后壁厚度（PVWT）、室间隔厚度（IVST）、E/E'比值、左心室质量指数（LVMI）、收缩压（≥140mmHg）和舒张压（≥90mmHg）与早期轻度 DHF 独立相关。
在一般中年人群中，动脉僵硬度的增加与早期轻度 DHF 独立相关，而与年龄、男性、BMI、PVWT、IVST、E/E'比值、LVMI 和高血压无关。在引入抗动脉粥样硬化治疗的情况下，所述的非侵入性技术可以允许进行随时间的连续测量，以监测动脉中 baPWV 的变化。
