Chen Jiamin, Jiang Wuxia, Shao Liming, Zhong Dandan, Wu Yihua, Cai Jianting
a Department of Gastroenterology , Second Affiliated Hospital, Zhejiang University College of Medicine , Hangzhou , China ;
b Department of Epidemiology and Health Statistics , Zhejiang University School of Public Health , Hangzhou , China.
Int J Food Sci Nutr. 2016 Nov;67(7):744-53. doi: 10.1080/09637486.2016.1197892. Epub 2016 Jun 30.
We conducted a meta-analysis to systematically evaluate the association between antioxidants intake and pancreatic cancer risk. Relevant articles were retrieved from PUBMED and EMBASE databases and standard meta-analysis methods were applied. Finally a total of 18 studies were included. Comparing the highest with lowest categories, higher dietary intakes of selenium, vitamin C, vitamin E, β-carotene and β-cryptoxanthin were significantly associated with reduced pancreatic cancer risk (for selenium, pooled OR = 0.47, 95%CI 0.26-0.85; for vitamin C, pooled OR = 0.68, 95%CI 0.57-0.80; for vitamin E, pooled OR = 0.70, 95%CI 0.62-0.81; for β-carotene, pooled OR = 0.74, 95%CI 0.56-0.98; for β-cryptoxanthin, pooled OR = 0.70, 95%CI 0.56-0.88). Lycopene intake was marginally associated with pancreatic cancer risk (pooled OR = 0.85, 95%CI 0.73-1.00), while no significant association was observed for α-carotene, lutein and zeaxanthin. In summary, higher dietary intake of selenium, vitamin C, vitamin E, β-carotene and β-cryptoxanthin was inversely associated with pancreatic cancer risk.
我们进行了一项荟萃分析，以系统评估抗氧化剂摄入量与胰腺癌风险之间的关联。从PUBMED和EMBASE数据库中检索相关文章，并应用标准的荟萃分析方法。最终共纳入18项研究。将最高摄入量组与最低摄入量组进行比较，较高的膳食硒、维生素C、维生素E、β-胡萝卜素和β-隐黄质摄入量与降低的胰腺癌风险显著相关（对于硒，合并OR = 0.47，95%CI 0.26 - 0.85；对于维生素C，合并OR = 0.68，95%CI 0.57 - 0.80；对于维生素E，合并OR = 0.70，95%CI 0.62 - 0.81；对于β-胡萝卜素，合并OR = 0.74，95%CI 0.56 - 0.98；对于β-隐黄质，合并OR = 0.70，95%CI 0.56 - 0.88）。番茄红素摄入量与胰腺癌风险呈边缘性关联（合并OR = 0.85，95%CI 0.73 - 1.00），而对于α-胡萝卜素、叶黄素和玉米黄质未观察到显著关联。总之，较高的膳食硒、维生素C、维生素E、β-胡萝卜素和β-隐黄质摄入量与胰腺癌风险呈负相关。
