Yanjun Yao, Jing Zhuang, Yifei Song, Gangzhao Gu, Chenxin Yan, Qiang Wei, Qiang Yan, Shuwen Han
Huzhou Central Hospital, Affiliated Huzhou Hospital, Zhejiang University School of Medicine, Huzhou, China.
Shulan International Medical school, Zhejiang Shuren University, Hangzhou, China.
Cancer Med. 2024 Jul;13(14):e7454. doi: 10.1002/cam4.7454.
Pancreatic cancer (PCA) is an extremely aggressive malignant cancer with an increasing incidence and a low five-year survival rate. The main reason for this high mortality is that most patients are diagnosed with PCA at an advanced stage, missing early treatment options and opportunities. As important nutrients of the human body, trace elements play an important role in maintaining normal physiological functions. Moreover, trace elements are closely related to many diseases, including PCA.
This review systematically summarizes the latest research progress on selenium, copper, arsenic, and manganese in PCA, elucidates their application in PCA, and provides a new reference for the prevention, diagnosis and treatment of PCA.
Trace elements such as selenium, copper, arsenic and manganese are playing an important role in the risk, pathogenesis, diagnosis and treatment of PCA. Meanwhile, they have a certain inhibitory effect on PCA, the mechanism mainly includes: promoting ferroptosis, inducing apoptosis, inhibiting metastasis, and inhibiting excessive proliferation.
胰腺癌（PCA）是一种极具侵袭性的恶性肿瘤，发病率不断上升，五年生存率较低。导致这种高死亡率的主要原因是大多数患者在晚期才被诊断出患有PCA，从而错过早期治疗选择和机会。微量元素作为人体重要的营养素，在维持正常生理功能方面发挥着重要作用。此外，微量元素与包括PCA在内的许多疾病密切相关。
本综述系统总结了硒、铜、砷和锰在PCA方面的最新研究进展，阐明了它们在PCA中的应用，为PCA的预防、诊断和治疗提供了新的参考。
硒、铜、砷和锰等微量元素在PCA的风险、发病机制、诊断和治疗中发挥着重要作用。同时，它们对PCA有一定的抑制作用，其机制主要包括：促进铁死亡、诱导凋亡、抑制转移和抑制过度增殖。
