Huang Ru-Lin, Liu Kai, Li Qingfeng
Department of Plastic & Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, China.
Regen Med. 2016 Jul;11(5):475-81. doi: 10.2217/rme-2016-0021. Epub 2016 Jun 30.
Large bone defect treatment is a key challenge due to the difficulty of functional and aesthetic reconstruction. A promising approach for bone regeneration is bone tissue engineering which is based on in vitro manipulation of seed cells, growth factors and bioscaffolds. However, many formidable conceptual and technical challenges impede clinical translation of experimental successes into clinical practices. An emerging strategy for bone regeneration is using the body as a bioreactor to cultivate the traditional triad and leveraging the body's own regenerative capacity to create new bone tissue. Based on the understanding of bone regeneration and in vivo bioreactor principle, we hypothesize that functional bone tissue may be eventually generated in vivo only using autologous costal periosteum, without participation of any exogenous elements.
由于功能和美学重建的困难，大骨缺损治疗是一项关键挑战。骨组织工程是一种很有前景的骨再生方法，它基于对种子细胞、生长因子和生物支架的体外操作。然而，许多巨大的概念和技术挑战阻碍了将实验成功转化为临床实践。一种新兴的骨再生策略是将身体用作生物反应器来培养传统的三联体，并利用身体自身的再生能力来创建新的骨组织。基于对骨再生和体内生物反应器原理的理解，我们假设仅使用自体肋骨骨膜最终可能在体内生成功能性骨组织，而无需任何外源性元素的参与。
