Garcia-Nuñez Marian, Quero Sara, Pedro-Botet Maria Lluisa, Barrabeig Irene, Avarez Josep, Campoy Irene, Sala Maria Rosa, Parraga-Niño Noemí, Minguell Sofia, Caylà Joan, Mateu Lourdes, Sabria Miquel
Infectious Diseases Unit, Fundació Institut d'Investigació Germans Trias i Pujol, Hospital Germans Trias i Pujol, Badalona, Spain E-08916.
Grupo de estudio de la Legionelosis, Autonomous University of Barcelona, Cerdanyola, Spain E-08913.
Future Microbiol. 2016 Jul;11:865-75. doi: 10.2217/fmb-2016-0013. Epub 2016 Jun 30.
To characterize the genetic diversity of unrelated Legionella pneumophila clinical isolates in Catalonia and compare with other European regions.
95 unrelated isolates were analyzed using monoclonal antibodies and sequence-based typing, 1989-2013.
The isolates showed a high diversity (IOD 0.964) with a predominance of some profiles (ST37-Phialdelphia, ST23-Philadelphia and ST1-OLDA). All regions had predominant sequence types (STs) that differed between regions, and only 3% of STs were shared between the three regions.
L. pneumophila clinical isolates from Catalonia presented a high diversity and can be used in epidemiological surveillance studies. The heterogeneous predominance of STs between European regions suggested a relationship between geographical distribution and virulence of some STs.
鉴定加泰罗尼亚地区非相关嗜肺军团菌临床分离株的遗传多样性，并与其他欧洲地区进行比较。
1989年至2013年期间，使用单克隆抗体和基于序列的分型方法对95株非相关分离株进行分析。
分离株显示出高度多样性（多样性指数0.964），某些谱系（ST37-费城型、ST23-费城型和ST1-OLDA型）占优势。所有地区都有占主导地位的序列类型（STs），各地区之间存在差异，三个地区之间仅3%的STs相同。
加泰罗尼亚地区的嗜肺军团菌临床分离株呈现出高度多样性，可用于流行病学监测研究。欧洲各地区STs的异质性优势表明某些STs的地理分布与毒力之间存在关联。
