Schandl Károly, Horváthy Dénes B, Doros Attila, Majzik Ernő, Schwarz Charlotte M, Csönge Lajos, Abkarovits Géza, Bucsi László, Lacza Zsombor
Institute of Clinical Experimental Research, Semmelweis University, Budapest, Tűzoltó u. 37-47, 1094, Hungary.
Saint George University Teaching Hospital of County-Fejér, Székesfehérvár, Seregélyesi u. 3., 8000, Hungary.
Int Orthop. 2016 Oct;40(10):2097-2104. doi: 10.1007/s00264-016-3246-8. Epub 2016 Jun 29.
Donor site pain affects 32-43 % of patients after anterior cruciate ligament surgery when the autograft is freshly harvested bone-patellar tendon-bone tissue. Our aim was to compare functional and morphological differences between donor sites with and without serum albumin-coated bone allograft filling.
After harvesting and implanting the graft, the tibia site was filled with either fresh autologous cancellous bone enhanced with albumin-coated allograft or autologous bone alone. The patella site was filled either with albumin-coated allograft or with blood clot. Knee function was evaluated by the VISA, Lysholm and IKDC scores and a visual analog scale of pain during standing, kneeling and crouching after six weeks and six months. Computed tomography was performed at six months for morphological evaluation.
At six weeks, both groups were still recovering from surgery and the overall knee function was still impaired but the functional scores were significantly higher in the Bone-Albumin group. The pain with crouching and kneeling was also lower as compared to controls. At six months, the knee function scores were close to normal, with a slight decrease in the controls. Pain at kneeling was still prominent in the controls, but significantly lower in the Bone-Albumin group. Computed tomography showed significantly smaller bone defects and higher bone density in the Bone-Albumin group.
Results from the present study indicate that donor site pain, a disturbing long-term side effect of bone-patellar tendon-bone surgery, is significantly reduced if bone buildup in the patella and the tibia is augmented by serum albumin-coated bone allografts.
当自体移植物为新鲜采集的骨-髌腱-骨组织时,供区疼痛影响32%-43%的前交叉韧带手术患者。我们的目的是比较使用和不使用血清白蛋白包被的骨同种异体移植填充的供区之间的功能和形态差异。
采集并植入移植物后,胫骨部位用白蛋白包被的同种异体移植物增强的新鲜自体松质骨或仅用自体骨填充。髌骨部位用白蛋白包被的同种异体移植物或血凝块填充。通过VISA、Lysholm和IKDC评分以及六周和六个月后站立、跪和蹲时的视觉模拟疼痛量表评估膝关节功能。六个月时进行计算机断层扫描以进行形态学评估。
六周时,两组仍在从手术中恢复,整体膝关节功能仍受损,但骨-白蛋白组的功能评分显著更高。与对照组相比,蹲和跪时的疼痛也更低。六个月时,膝关节功能评分接近正常,对照组略有下降。对照组跪时的疼痛仍然很突出,但骨-白蛋白组显著更低。计算机断层扫描显示骨-白蛋白组的骨缺损明显更小,骨密度更高。
本研究结果表明,如果用血清白蛋白包被的骨同种异体移植物增加髌骨和胫骨的骨量,则骨-髌腱-骨手术令人困扰的长期副作用——供区疼痛会显著减轻。