College of Dentistry, Lorestan University of Medical Sciences, Khorramabad, Iran.
Young Researchers and Elite Club, Tabriz Branch, Islamic Azad University, Tabriz, Iran.
Biomed Eng Online. 2024 Nov 27;23(1):122. doi: 10.1186/s12938-024-01318-9.
Periodontal infection is a long-lasting inflammatory condition caused by the growth and development of an abnormal and harmful community of microorganisms. This destructive illness leads to the loss of the tissues that support the teeth, degradation of the bone surrounding the teeth, and eventually tooth loss. To treat oral infections, it is necessary to use nonsurgical methods such as antibiotics. However, the indiscriminate and incorrect use of antibiotics results in drug resistance. Among these alternate therapeutic options, using nanoparticles to treat infectious dental disease was particularly significant. Consequently, researchers have worked to develop an effective and satisfactory drug delivery method for treating periodontal and dental illnesses. Albumin nanoparticles serve a considerable function as carriers in the drug delivery of chemical and biomolecular medications, such as anticancer treatments; they have several advantages, including biocompatibility and biodegradability, and they are well-tolerated with no adverse effects. Albumin nanoparticles have several benefits over other nanomaterials. Protein nanocarriers provide advantages such as biocompatibility, biodegradability, reduced immunogenicity, and lower cytotoxicity. Furthermore, this nanoparticle demonstrated significant intrinsic antibacterial properties without being loaded with antibiotic medicines. As a medication and antibacterial nanoparticle delivery method, albumin nanoparticles have substantial applications in periodontal and dental infectious disorders such as periodontal infection, apical periodontitis, and peri-implantitis. As a result, in this article, we studied the usage of albumin nanoparticles in dental disorders.
牙周感染是一种由异常和有害的微生物群落生长和发展引起的长期炎症状态。这种破坏性疾病会导致支持牙齿的组织丧失、牙齿周围骨骼退化，最终导致牙齿脱落。为了治疗口腔感染，需要使用抗生素等非手术方法。然而，抗生素的滥用和误用导致了耐药性的产生。在这些替代治疗方案中，使用纳米颗粒治疗感染性牙科疾病尤为重要。因此，研究人员致力于开发一种有效且令人满意的药物输送方法，以治疗牙周病和牙科疾病。白蛋白纳米颗粒在化学和生物分子药物（如抗癌治疗）的药物输送中作为载体发挥着重要作用；它们具有生物相容性和可生物降解性等优点，并且耐受性良好，没有不良反应。白蛋白纳米颗粒优于其他纳米材料。蛋白质纳米载体具有生物相容性、可生物降解性、降低免疫原性和更低的细胞毒性等优点。此外，这种纳米颗粒在不加载抗生素药物的情况下表现出显著的固有抗菌特性。作为一种药物和抗菌纳米颗粒输送方法，白蛋白纳米颗粒在牙周病和牙科感染性疾病（如牙周炎、根尖周炎和种植体周围炎）中有广泛的应用。因此，在本文中，我们研究了白蛋白纳米颗粒在牙科疾病中的应用。
