植物源可食用纳米颗粒作为一种治疗疾病的新方法。
Plant derived edible nanoparticles as a new therapeutic approach against diseases.
作者信息
Zhang Mingzhen, Viennois Emilie, Xu Changlong, Merlin Didier
机构信息
Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA; Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA, USA.
Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA; The 2nd Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
出版信息
Tissue Barriers. 2016 Feb 11;4(2):e1134415. doi: 10.1080/21688370.2015.1134415. eCollection 2016 Apr-Jun.
Abstract
In plant cells, nanoparticles containing miRNA, bioactive lipids and proteins serve as extracellular messengers to mediate cell-cell communication in a manner similar to the exosomes secreted by mammalian cells. Notably, such nanoparticles are edible. Moreover, given the proper origin and cargo, plant derived edible nanoparticles could function in interspecies communication and may serve as natural therapeutics against a variety of diseases. In addition, nanoparticles made of plant-derived lipids may be used to efficiently deliver specific drugs. Plant derived edible nanoparticles could be more easily scaled up for mass production, compared to synthetic nanoparticles. In this review, we discuss recent significant developments pertaining to plant derived edible nanoparticles and provide insight into the use of plants as a bio-renewable, sustainable, diversified platform for the production of therapeutic nanoparticles.
摘要
在植物细胞中，含有微小RNA、生物活性脂质和蛋白质的纳米颗粒作为细胞外信使，以类似于哺乳动物细胞分泌的外泌体的方式介导细胞间通讯。值得注意的是，这类纳米颗粒是可食用的。此外，鉴于其合适的来源和所载物质，植物源可食用纳米颗粒可在种间通讯中发挥作用，并可能作为针对多种疾病的天然疗法。此外，由植物源脂质制成的纳米颗粒可用于高效递送特定药物。与合成纳米颗粒相比，植物源可食用纳米颗粒更容易扩大规模进行大规模生产。在本综述中，我们讨论了与植物源可食用纳米颗粒相关的近期重大进展，并深入探讨了将植物用作生产治疗性纳米颗粒的生物可再生、可持续、多样化平台的用途。
相似文献
1
Plant derived edible nanoparticles as a new therapeutic approach against diseases.植物源可食用纳米颗粒作为一种治疗疾病的新方法。
Tissue Barriers. 2016 Feb 11;4(2):e1134415. doi: 10.1080/21688370.2015.1134415. eCollection 2016 Apr-Jun.
2
Research status and challenges of plant-derived exosome-like nanoparticles.植物源外泌体样纳米颗粒的研究现状与挑战
Biomed Pharmacother. 2024 May;174:116543. doi: 10.1016/j.biopha.2024.116543. Epub 2024 Apr 11.
3
Coffee-Derived Exosome-Like Nanoparticles: Are They the Secret Heroes?咖啡衍生的外泌体样纳米颗粒：它们是秘密英雄吗？
Turk J Gastroenterol. 2023 Feb;34(2):161-169. doi: 10.5152/tjg.2022.21895.
4
Interspecies communication between plant and mouse gut host cells through edible plant derived exosome-like nanoparticles.植物和鼠肠宿主细胞通过可食用植物衍生的外体样纳米颗粒进行种间通讯。
Mol Nutr Food Res. 2014 Jul;58(7):1561-73. doi: 10.1002/mnfr.201300729. Epub 2014 May 19.
5
Exosomes as novel bio-carriers for gene and drug delivery.外泌体作为用于基因和药物递送的新型生物载体。
Int J Pharm. 2017 Apr 15;521(1-2):167-175. doi: 10.1016/j.ijpharm.2017.02.038. Epub 2017 Feb 17.
6
Current understanding of plant-derived exosome-like nanoparticles in regulating the inflammatory response and immune system microenvironment.目前对植物来源的外泌体样纳米颗粒在调节炎症反应和免疫系统微环境方面的理解。
Pharmacol Res. 2023 Apr;190:106733. doi: 10.1016/j.phrs.2023.106733. Epub 2023 Mar 15.
7
Therapeutic use of curcumin-encapsulated and curcumin-primed exosomes.姜黄素包封和姜黄素引发的外泌体的治疗用途。
J Cell Physiol. 2019 Jun;234(6):8182-8191. doi: 10.1002/jcp.27615. Epub 2018 Oct 14.
8
Uptake of MicroRNAs from Exosome-Like Nanovesicles of Edible Plant Juice by Rat Enterocytes.食用植物汁外泌体样纳米囊泡中 microRNAs 被大鼠肠细胞摄取。
Int J Mol Sci. 2021 Apr 3;22(7):3749. doi: 10.3390/ijms22073749.
9
Exosomes: cell-created drug delivery systems.外泌体：细胞衍生的药物递送系统。
Mol Cell Biochem. 2019 Sep;459(1-2):1-6. doi: 10.1007/s11010-019-03545-4. Epub 2019 May 9.
10
Recent Trends in Nanotechnology Toward CNS Diseases: Lipid-Based Nanoparticles and Exosomes for Targeted Therapeutic Delivery.纳米技术针对中枢神经系统疾病的最新趋势：用于靶向治疗递送的脂质纳米颗粒和外泌体
Int Rev Neurobiol. 2016;130:1-40. doi: 10.1016/bs.irn.2016.05.002. Epub 2016 Jun 21.
引用本文的文献
1
(Thunb.) DC. [Asteraceae] Rhizome-Derived Exosome-like Nanoparticles Suppress Lipopolysaccharide-Induced Inflammation by Reducing Toll-like Receptor 4 Expression in BV-2 Murine Microglial Cells.（菊科）DC. 来源于根茎的类外泌体纳米颗粒通过降低BV-2小鼠小胶质细胞中Toll样受体4的表达来抑制脂多糖诱导的炎症。
Pharmaceuticals (Basel). 2025 Jul 24;18(8):1099. doi: 10.3390/ph18081099.
2
Current progress of plant-derived exosome-like nanovesicles on the regulation of osteoporosis and osteoarthritis.植物源外泌体样纳米囊泡在骨质疏松症和骨关节炎调控方面的研究进展
Ann Med. 2025 Dec;57(1):2549524. doi: 10.1080/07853890.2025.2549524. Epub 2025 Aug 22.
3
Advancing cancer therapy: Nanomaterial-based encapsulation strategies for enhanced delivery and efficacy of curcumin.推进癌症治疗：基于纳米材料的包封策略以增强姜黄素的递送及疗效
Mater Today Bio. 2025 Jun 9;33:101963. doi: 10.1016/j.mtbio.2025.101963. eCollection 2025 Aug.
4
Extraction of anthocyanins from purple sweet potato: evaluation of anti-inflammatory effects in a rheumatoid arthritis animal model, mechanistic studies on inflammatory cells, and development of exosome-based delivery for enhanced targeting.从紫薯中提取花青素：类风湿性关节炎动物模型中的抗炎作用评估、炎症细胞的机制研究以及基于外泌体递送以增强靶向性的开发
Front Immunol. 2025 Jun 9;16:1559874. doi: 10.3389/fimmu.2025.1559874. eCollection 2025.
5
Advancements in Plant-Derived sRNAs Therapeutics: Classification, Delivery Strategies, and Therapeutic Applications.植物源小RNA疗法的进展：分类、递送策略及治疗应用
Int J Mol Sci. 2025 Apr 30;26(9):4277. doi: 10.3390/ijms26094277.
6
Tea leaf exosome-like nanoparticles (TELNs) improve oleic acid-induced lipid metabolism by regulating miRNAs in HepG-2 cells.茶叶外泌体样纳米颗粒（TELNs）通过调节HepG-2细胞中的miRNAs改善油酸诱导的脂质代谢。
Bioresour Bioprocess. 2025 Feb 10;12(1):9. doi: 10.1186/s40643-025-00844-1.
7
A Comprehensive Review on Exploring the Potential of Phytochemicals and Biogenic Nanoparticles for the Treatment of Antimicrobial-Resistant Pathogenic Bacteria.关于探索植物化学物质和生物源纳米颗粒治疗耐抗菌性病原体细菌潜力的综合综述
Curr Microbiol. 2025 Jan 18;82(2):90. doi: 10.1007/s00284-025-04064-w.
8
Polycystic Ovary Syndrome and the Potential for Nanomaterial-Based Drug Delivery in Therapy of This Disease.多囊卵巢综合征以及基于纳米材料的药物递送在该疾病治疗中的潜力。
Pharmaceutics. 2024 Dec 4;16(12):1556. doi: 10.3390/pharmaceutics16121556.
9
Cross-kingdom regulation of plant microRNAs: potential application in crop improvement and human disease therapeutics.植物微小RNA的跨界调控：在作物改良和人类疾病治疗中的潜在应用。
Front Plant Sci. 2024 Dec 17;15:1512047. doi: 10.3389/fpls.2024.1512047. eCollection 2024.
10
New insights of engineering plant exosome-like nanovesicles as a nanoplatform for therapeutics and drug delivery.工程化植物外泌体样纳米囊泡作为治疗和药物递送纳米平台的新见解。
Extracell Vesicles Circ Nucl Acids. 2022 Jun 29;3(2):150-162. doi: 10.20517/evcna.2021.25. eCollection 2022.
本文引用的文献
1
Hyaluronic acid-functionalized polymeric nanoparticles for colon cancer-targeted combination chemotherapy.用于结肠癌靶向联合化疗的透明质酸功能化聚合物纳米颗粒
Nanoscale. 2015 Nov 14;7(42):17745-55. doi: 10.1039/c5nr04831a. Epub 2015 Oct 12.
2
Diagnostic profiling of salivary exosomal microRNAs in oral lichen planus patients.口腔扁平苔藓患者唾液外泌体微小RNA的诊断分析
Oral Dis. 2015 Nov;21(8):987-93. doi: 10.1111/odi.12374. Epub 2015 Oct 24.
3
Potential functional applications of extracellular vesicles: a report by the NIH Common Fund Extracellular RNA Communication Consortium.细胞外囊泡的潜在功能应用：NIH 共同基金细胞外 RNA 通讯联盟的报告。
J Extracell Vesicles. 2015 Aug 28;4:27575. doi: 10.3402/jev.v4.27575. eCollection 2015.
4
Oral administration of pH-sensitive curcumin-loaded microparticles for ulcerative colitis therapy.口服pH敏感型载姜黄素微粒用于溃疡性结肠炎治疗
Colloids Surf B Biointerfaces. 2015 Nov 1;135:379-385. doi: 10.1016/j.colsurfb.2015.07.081. Epub 2015 Aug 1.
5
The Intestinal Transport of Bovine Milk Exosomes Is Mediated by Endocytosis in Human Colon Carcinoma Caco-2 Cells and Rat Small Intestinal IEC-6 Cells.牛乳外泌体在人结肠癌Caco-2细胞和大鼠小肠IEC-6细胞中的肠道转运是通过内吞作用介导的。
J Nutr. 2015 Oct;145(10):2201-6. doi: 10.3945/jn.115.218586. Epub 2015 Aug 12.
6
Facile Synthesis of Gold Nanospheres Modified by Positively Charged Mesoporous Silica, Loaded with Near-Infrared Fluorescent Dye, for in Vivo X-ray Computed Tomography and Fluorescence Dual Mode Imaging.简便合成带正电荷的介孔二氧化硅修饰的金纳米球，负载近红外荧光染料，用于体内X射线计算机断层扫描和荧光双模式成像。
ACS Appl Mater Interfaces. 2015 Aug 12;7(31):17287-97. doi: 10.1021/acsami.5b04359. Epub 2015 Jul 30.
7
Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death.柠檬来源的纳米囊泡通过诱导TRAIL介导的细胞死亡抑制癌细胞增殖并抑制慢性粒细胞白血病异种移植瘤生长。
Oncotarget. 2015 Aug 14;6(23):19514-27. doi: 10.18632/oncotarget.4004.
8
Grapefruit-Derived Nanovectors Use an Activated Leukocyte Trafficking Pathway to Deliver Therapeutic Agents to Inflammatory Tumor Sites.源自葡萄柚的纳米载体利用激活的白细胞运输途径将治疗剂递送至炎性肿瘤部位。
Cancer Res. 2015 Jun 15;75(12):2520-9. doi: 10.1158/0008-5472.CAN-14-3095. Epub 2015 Apr 16.
9
A protocol for exosome isolation and characterization: evaluation of ultracentrifugation, density-gradient separation, and immunoaffinity capture methods.外泌体分离与表征方案：超速离心、密度梯度分离和免疫亲和捕获方法的评估
Methods Mol Biol. 2015;1295:179-209. doi: 10.1007/978-1-4939-2550-6_15.
10
Salivary extracellular noncoding RNA: emerging biomarkers for molecular diagnostics.唾液细胞外非编码RNA：分子诊断中新兴的生物标志物
Clin Ther. 2015 Mar 1;37(3):540-51. doi: 10.1016/j.clinthera.2015.02.017. Epub 2015 Mar 18.
Zotero 插件