Slocombe R F, Mitten R, Mason T A
Veterinary Clinical Centre, University of Melbourne, Werribee, Victoria.
Aust Vet J. 1989 May;66(5):147-50. doi: 10.1111/j.1751-0813.1989.tb09782.x.
Clinical and pathological studies of a neurological disorder of 3 adult Rottweiler dogs are described. Dogs developed proprioceptive losses involving the limbs, leading to progressively worsening ataxia and hypermetria. Blood and CSF fluid analyses were normal and radiographs and myelograms showed no compressive lesions of the spinal cord. At necropsy, severe demyelination of the dorsal and lateral funiculi of the cervical spinal cord was visible grossly. Microscopically there was more extensive, symmetrical involvement of the spinal cord and brain than was apparent grossly, with demyelination of white matter tracts and sparing of axons in affected areas. These changes were considered diagnostic for leucoencephalomyelopathy. This condition has not been previously reported in Australia, and is probably transmitted genetically, presumably as an autosomal recessive trait.
描述了3只成年罗威纳犬神经疾病的临床和病理研究。这些犬出现涉及四肢的本体感觉丧失，导致共济失调和辨距不良逐渐加重。血液和脑脊液分析正常，X线片和脊髓造影显示脊髓无压迫性病变。尸检时，肉眼可见颈脊髓背侧和外侧索严重脱髓鞘。显微镜下，脊髓和脑的受累范围比肉眼所见更广泛、更对称，受累区域白质束脱髓鞘而轴突保留。这些变化被认为是白质脑脊髓病的诊断依据。这种疾病以前在澳大利亚尚未有报道，可能是遗传传播的，推测为常染色体隐性性状。
