Cork L C, Troncoso J C, Price D L, Stanley E F, Griffin J W
J Neuropathol Exp Neurol. 1983 May;42(3):286-96. doi: 10.1097/00005072-198305000-00006.
Canine neuroaxonal dystrophy, a newly recognized familial disorder in Rottweiler dogs, is characterized by progressive sensory ataxia. Two of four dogs studied clinically were autopsied and the cerebellum was mildly atrophic. Massive numbers of axonal spheroids were present in many regions of the neuraxis but were most prominent in the dorsal horn of the spinal cord and the nuclei gracilis and cuneatus. Ultrastructurally, spheroids appeared to be swellings of distal axons which were filled with accumulations of smooth membrane-bound vesicles, membranous lamellae, dense bodies, and other organelles. Neuropathological changes were similar to those identified in human neuroaxonal dystrophy.
犬神经轴突营养不良是一种新近在罗威纳犬中发现的家族性疾病，其特征为进行性感觉性共济失调。对临床研究的四只犬中的两只进行了尸检，发现小脑轻度萎缩。在神经轴的许多区域都有大量轴突球状体，但在脊髓背角以及薄束核和楔束核中最为明显。在超微结构上，球状体似乎是远端轴突的肿胀，内部充满了光滑的膜结合小泡、膜性薄片、致密小体和其他细胞器的聚积物。神经病理学变化与人类神经轴突营养不良中所发现的变化相似。
