Atrens D M, van der Reest A, Balleine B W, Menéndez J A, Siviy S M
Department of Psychology, University of Sydney, N.S.W. Australia.
Alcohol. 1989 May-Jun;6(3):183-7. doi: 10.1016/0741-8329(89)90016-5.
The mechanisms of ethanol's hyperglycemic and hypothermic effects were investigated by comparing the effects of ethanol with those of tertiary butanol. Tertiary butanol is an intoxicant like ethanol, but unlike ethanol it is only minimally metabolized. Consequently, tertiary butanol does not produce appreciable amounts of active metabolites or energy. Tertiary butanol exerts its neural effects primarily by directly altering the physico-chemical properties of nerve cell membranes. It was found that ethanol and tertiary butanol produce hyperglycemic and hypothermic effects whose magnitude and time course are nearly identical. These data suggest that the hyperglycemic and hypothermic effects of ethanol represent a primary physico-chemical effect on nerve cell membranes and are not secondary to its energy content or metabolites.
通过比较乙醇与叔丁醇的作用，研究了乙醇的高血糖和体温过低效应机制。叔丁醇是一种与乙醇类似的麻醉剂，但与乙醇不同的是，它仅被极少代谢。因此，叔丁醇不会产生大量的活性代谢物或能量。叔丁醇主要通过直接改变神经细胞膜的物理化学性质来发挥其神经效应。研究发现，乙醇和叔丁醇产生的高血糖和体温过低效应，其程度和时间进程几乎相同。这些数据表明，乙醇的高血糖和体温过低效应代表了对神经细胞膜的一种主要物理化学效应，并非继发于其能量含量或代谢物。
