Hagman M, Eriksson T, Kitson K E
Department of Chemistry and Biochemistry, Massey University, Palmerston North, New Zealand.
Alcohol Clin Exp Res. 1993 Apr;17(2):299-303. doi: 10.1111/j.1530-0277.1993.tb00767.x.
Both metabolic and nonmetabolic mechanisms have been proposed to the plasma amino acid decreasing effect of an acute ethanol load. We used tert-butanol, an alcohol that is only minimally metabolized, as a tool to explain the mechanism behind the amino acid decreasing effect of ethanol. Acute administration of tert-butanol was found to exert a decreasing effect on rat serum amino acid concentrations similar to that of ethanol, indicating that the mechanism of the amino acid decreasing effect of ethanol is primarily due to ethanol itself and not to its oxidation. Ethanol and tert-butanol also had similar effects on liver amino acid concentrations, including an increase in the glycine concentration and decrease in the concentrations of glutamate, alanine, leucine, and tyrosine.
代谢和非代谢机制均被认为与急性乙醇负荷导致血浆氨基酸减少的效应有关。我们使用叔丁醇（一种仅极少被代谢的醇类）作为工具来解释乙醇导致氨基酸减少效应背后的机制。结果发现，急性给予叔丁醇对大鼠血清氨基酸浓度产生的降低效应与乙醇相似，这表明乙醇导致氨基酸减少效应的机制主要归因于乙醇本身，而非其氧化作用。乙醇和叔丁醇对肝脏氨基酸浓度也有类似影响，包括甘氨酸浓度升高以及谷氨酸、丙氨酸、亮氨酸和酪氨酸浓度降低。
