Baker R C, Sorensen S M, Deitrich R A
Alcohol Clin Exp Res. 1982 Spring;6(2):247-51. doi: 10.1111/j.1530-0277.1982.tb04970.x.
The metabolism of tertiary butanol has been considered to be limited to direct conjugation of the hydroxyl group. Therefore, the alcohol has been used to differentiate between the direct effects of ethanol and those caused by metabolism or metabolic products of ethanol. The in vitro oxidation of tertiary butanol has been reported, and in this report we describe the in vivo oxidation of tertiary butanol. Radiolabeled and stable isotope-labeled acetone was recovered from animals treated with corresponding labeled t-butanol. 14CO2 was also recovered from animals treated with [14C]t-butanol.
叔丁醇的代谢被认为仅限于羟基的直接结合。因此，该醇类被用于区分乙醇的直接作用与由乙醇代谢或代谢产物引起的作用。已有叔丁醇体外氧化的报道，在本报告中，我们描述了叔丁醇的体内氧化情况。从用相应标记的叔丁醇处理的动物体内回收了放射性标记和稳定同位素标记的丙酮。在用[¹⁴C]叔丁醇处理的动物体内也回收了¹⁴CO₂。
