Kawahara R, Matsuda K, Ishida A, Takeshita H, Okubo I, Tanaka T, Sakamoto T, Takasu J
Department of Neuro-Psychiatry, Tottori University School of Medicine, Yonago, Japan.
No To Shinkei. 1989 Feb;41(2):135-41.
To understand the epileptic phenomenon in the immature brain and to investigate whether or not the epileptogenesis acquired in young age is retained after maturation, we carried out the amygdaloid kindling preparation (AM-K) on rat. Ten 3-week-old Wistar rats (3-week-old group) and ten 10-week-old rats (10-week-old group) were stimulated every 2 hours during 09:00-17:00, from five days after operation (Experiment 1). Nine kindled weanling rats (K-group) and ten weanling rats with no stimulation only electrodes implantation (non-K-group) were rekindled upon maturization (Experiment II). Stages of AM-K were classified according to the criteria of Racine. The results obtained were as follows: 1) The 3-week-old group needed significantly fewer stimulations and a shorter AD-durations during early stages (C0-2) of amygdaloid kindling, in comparison with the 10-week-old group. However, there was no significant difference between the two groups as to stimulations and AD-duration during later stages (C3-4) of the kindling. 2) The K-group were rekindled significantly fewer stimulations and a shorter AD-durations than non-K group during early stages. On the other hand, there was not significant difference between the two groups as to stimulation and AD-duration during later stages of the kindling. From the results, the following conclusions were made; The seizure susceptibility of weanling rat's limbic system is high and the epileptogenesis in the limbic system can be maintained even up to adulthood.
为了解未成熟大脑中的癫痫现象，并研究幼年获得的癫痫发生在成熟后是否会保留，我们对大鼠进行了杏仁核点燃制备（AM-K）实验。在术后第5天开始的09:00至17:00期间，每隔2小时对10只3周龄的Wistar大鼠（3周龄组）和10只10周龄的大鼠（10周龄组）进行刺激（实验1）。9只点燃的断奶大鼠（K组）和10只仅植入电极未接受刺激的断奶大鼠（非K组）在成熟后再次进行点燃实验（实验II）。根据Racine标准对AM-K的阶段进行分类。得到的结果如下：1）与10周龄组相比，3周龄组在杏仁核点燃早期阶段（C0-2）所需的刺激次数显著减少，AD持续时间更短。然而，在点燃后期阶段（C3-4），两组在刺激次数和AD持续时间方面没有显著差异。2）在早期阶段，K组再次点燃所需的刺激次数显著少于非K组，AD持续时间也更短。另一方面，在点燃后期阶段，两组在刺激次数和AD持续时间方面没有显著差异。根据这些结果，得出以下结论：断奶大鼠边缘系统的癫痫易感性较高，边缘系统中的癫痫发生甚至可以维持到成年期。
