掺入控释微球中的阿霉素的体内活性增强。
Enhanced in vivo activity of adriamycin incorporated into controlled release microspheres.
作者信息
Jones C, Burton M A, Gray B N
机构信息
University Department of Surgery, Royal Perth Hospital, Australia.
出版信息
Br J Cancer. 1989 May;59(5):743-5. doi: 10.1038/bjc.1989.155.
A comparison of the cytotoxic effectiveness of adriamycin incorporated into ion exchange microspheres with conventional chemotherapeutic use of adriamycin was carried out in a rat tumour model. Drug microspheres were targeted to the tumours by embolisation into the arterial supply of the hind limb bearing the tumour. Microspheres were found to embolise in tumour tissue at concentrations of up to 39 times that of the surrounding normal tissue. As a result, adriamycin microsphere therapy was found to retard significantly (P less than 0.01) tumour growth rates compared to growth rates associated with similar doses of adriamycin delivered as free drug rather than bound to controlled release microspheres. Equivalent sham microsphere treatments showed no significant difference in tumour growth rates compared with the control group. Adriamycin loaded on to ion exchange microspheres holds strong potential for treatment of human malignancy.
在大鼠肿瘤模型中，对负载于离子交换微球中的阿霉素与传统化疗使用阿霉素的细胞毒性效果进行了比较。通过栓塞至荷瘤后肢的动脉供血处，将药物微球靶向输送至肿瘤部位。结果发现，微球在肿瘤组织中的栓塞浓度高达周围正常组织的39倍。因此，与以游离药物而非结合于控释微球形式给予相似剂量阿霉素相比，阿霉素微球疗法显著（P<0.01）延缓了肿瘤生长速度。等效的假微球治疗与对照组相比，肿瘤生长速度无显著差异。负载于离子交换微球上的阿霉素在治疗人类恶性肿瘤方面具有强大潜力。
Zotero 插件