Harjai M M, Puri B, Amaresh N B
Reader in Surgery and Paediatric Surgeon, Department of Surgery, Armed Forces Medical College, Pune - 411040.
Classified Specialist in Surgery and Paediatric Surgery, Command Hospital (Southern Command), Pune.
Med J Armed Forces India. 2001 Jan;57(1):42-3. doi: 10.1016/S0377-1237(01)80089-7. Epub 2011 Jul 21.
Short bowel syndrome, a devastating outcome after major intestinal resection, manifests as malabsorption and diarrhoea. Improved outcome in recent years has come about with better understanding of the disease and its sequelae. Medical therapy using H2 receptor antagonists, loperamide and growth hormone analogues has been found useful. Total parenteral nutrition has revolutionized the outcome of this crippling disorder. Diverse spectrums of surgical procedures aimed at deceleration of intestinal transit and intestinal lengthening have not found favour in clinical practice. Intestinal transplantation remains the only viable option when intestinal adaptation is inadequate and complications of total parenteral nutrition ensue.
短肠综合征是肠道大部切除术后的严重后果，表现为吸收不良和腹泻。近年来，随着对该疾病及其后遗症的深入了解，治疗效果有所改善。已发现使用H2受体拮抗剂、洛哌丁胺和生长激素类似物进行药物治疗是有效的。全胃肠外营养彻底改变了这种致残性疾病的治疗结果。旨在减缓肠道传输和延长肠道长度的各种手术方法在临床实践中并未受到青睐。当肠道适应性不足且出现全胃肠外营养并发症时，肠道移植仍然是唯一可行的选择。
