Sasaki N, Saito Y, Shinomiya M, Kanzaki T, Ishikawa Y, Mori S, Kobayashi J, Murano S, Nishide T, Morisaki N
Department of Internal Medicine, Kawatetsu Chiba Hospital, Japan.
Clin Ther. 1990 Mar-Apr;12(2):157-64.
Thirty-four hyperlipoproteinemic, hypertensive patients received 5 mg of pindolol twice daily for 12 weeks. During pindolol administration, there were significant decreases in serum triglyceride levels and increases in high-density lipoprotein cholesterol (HDL-C) levels, while total cholesterol levels did not change. Serum levels of very-low-density lipoprotein (VLDL) triglyceride and VLDL cholesterol decreased over time as HDL-C increased. There was a significant increase in low-density lipoprotein cholesterol at week 12. Apolipoprotein (apo) A-I, A-II, and B levels did not change during pindolol administration, but apo C-II, C-III, and E levels decreased significantly. Lipoprotein lipase activity in heparin-treated plasma was significantly higher after pindolol administration. The results suggest that the reduction in triglyceride levels and increase in HDL-C after pindolol are partly a response to an increase in the hydrolysis of VLDL resulting from an increase in lipoprotein lipase activity.
34名高脂血症、高血压患者每日两次服用5毫克吲哚洛尔，持续12周。在服用吲哚洛尔期间，血清甘油三酯水平显著下降，高密度脂蛋白胆固醇（HDL-C）水平升高，而总胆固醇水平未发生变化。随着HDL-C升高，极低密度脂蛋白（VLDL）甘油三酯和VLDL胆固醇的血清水平随时间下降。在第12周时低密度脂蛋白胆固醇显著升高。在服用吲哚洛尔期间，载脂蛋白（apo）A-I、A-II和B水平未发生变化，但apo C-II、C-III和E水平显著下降。服用吲哚洛尔后，肝素处理血浆中的脂蛋白脂肪酶活性显著更高。结果表明，吲哚洛尔治疗后甘油三酯水平降低和HDL-C升高，部分原因是脂蛋白脂肪酶活性增加导致VLDL水解增加。
