Saku K, Ying H, Arakawa K
Department of Internal Medicine, Fukuoka University School of Medicine, Japan.
Clin Ther. 1990 Mar-Apr;12(2):132-8.
Twenty-two patients with mild to moderate hypertension received 20 mg of pinacidil daily for six weeks, followed by 40 mg daily for another six weeks. Levels of serum triglyceride and apolipoproteins C-II and C-III decreased significantly; high-density lipoprotein cholesterol levels increased significantly during treatment. These changes were more prominent in patients with total triglyceride levels of 150 mg/dl or over. The results suggest that pinacidil has a preferential action on triglyceride-rich lipoprotein metabolism.
22例轻至中度高血压患者每日服用20毫克吡那地尔，持续六周，随后六周每日服用40毫克。血清甘油三酯、载脂蛋白C-II和C-III水平显著下降；治疗期间高密度脂蛋白胆固醇水平显著升高。这些变化在总甘油三酯水平为150毫克/分升或以上的患者中更为显著。结果表明，吡那地尔对富含甘油三酯的脂蛋白代谢具有优先作用。
