载脂蛋白E4（ApoE e4）对伴或不伴抑郁症患者血压的影响。
The effect of ApoE e4 on blood pressure in patients with and without depression.
作者信息
Hestad Knut A, Engedal Knut, Whist Jon Elling, Farup Per G
机构信息
Department of Research, Innlandet Hospital Trust, Brumunddal, Norway; Department of Psychology, Faculty of Social Sciences and Technology Management, Norwegian University of Science and Technology, Trondheim, Norway; Department of Public Health, Hedmark University College, Elverum, Norway.
Norwegian Center for Aging and Health, Vestfold Health Trust, Tønsberg, Norway.
出版信息
Neuropsychiatr Dis Treat. 2016 Jun 14;12:1365-70. doi: 10.2147/NDT.S106933. eCollection 2016.
INTRODUCTION
Depression is considered an independent risk factor for hypertension, particularly for people with recurrent episodes or a long history of depression. Another risk factor for cardiovascular disease is the Apolipoprotein E e4 allele (ApoE e4). The aim of this study was to examine how ApoE e4 was related to blood pressure (BP) in patients with depression and a control group.
METHODS
A total of 78 patients, 49 with depression and 29 without, all recruited from the same hospital, underwent ApoE e genotyping (24 had at least one ApoE e4 allele) and examination of BP.
RESULTS
In the depression group, but not in the control group, both systolic and diastolic BP were significantly higher in patients with ApoE e4 than in those without. The effect of ApoE e4 on BP differed significantly between the two groups.
CONCLUSION
Our findings showed that the effect of ApoE e4 on BP differed between the patients with depression and the control group. In patients with depression, ApoE e4 was associated with an increase in BP. We suggest that patients with depression and ApoE e4-positive status are particularly prone to develop BP elevation.
引言
抑郁症被认为是高血压的一个独立危险因素，尤其是对于有复发史或长期抑郁病史的人。心血管疾病的另一个危险因素是载脂蛋白E e4等位基因（ApoE e4）。本研究的目的是探讨ApoE e4与抑郁症患者及对照组血压（BP）之间的关系。
方法
从同一家医院招募了78名患者，其中49名患有抑郁症，29名没有抑郁症，对他们进行了ApoE基因分型（24人至少有一个ApoE e4等位基因）并检查了血压。
结果
在抑郁症组中，而不是在对照组中，携带ApoE e4的患者收缩压和舒张压均显著高于未携带的患者。两组之间ApoE e4对血压的影响差异显著。
结论
我们的研究结果表明，ApoE e4对血压的影响在抑郁症患者和对照组之间存在差异。在抑郁症患者中，ApoE e4与血压升高有关。我们建议，患有抑郁症且ApoE e4呈阳性的患者特别容易出现血压升高。
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