一次性鞘内注射曲安奈德对进展型多发性硬化症患者脑脊液氧化还原电位的影响：一项初步研究。
One-time intrathecal triamcinolone acetonide application alters the redox potential in cerebrospinal fluid of progressive multiple sclerosis patients: a pilot study.
作者信息
Müller Thomas, Herrling Thomas, Lütge Sven, Lohse Lutz, Öhm Gabi, Jung Katinka
机构信息
Department of Neurology, St. Joseph Hospital, Gartenstrasse 1, 13088 Berlin, Germany.
Gematria Test Lab GmbH, Berlin, Germany.
出版信息
Ther Adv Neurol Disord. 2016 Jul;9(4):264-8. doi: 10.1177/1756285616636551. Epub 2016 Mar 9.
INTRODUCTION
Cerebrospinal fluid analysis may provide insight into the interplay between chronic inflammation and response to treatment.
OBJECTIVES
To demonstrate the impact of one intrathecal triamcinolone injection on the redox potential and on ascorbyl radical appearance in the cerebrospinal fluid of chronic progressive multiple sclerosis patients.
METHODS
A total of 16 patients received 40 mg triamcinolone. Electron-spin resonance spectroscopy measured the oxidation range after copper ion [Cu (II)] addition and ascorbyl-radical bioavailability.
RESULTS
There was an increase of Cu (II) ion absorption, which reflects an augmented content of reduced proteins. Ascorbyl radicals were present in contrast to healthy controls according to the literature.
CONCLUSION
Intrathecal steroid application alters the redox potential in cerebrospinal fluid. Our findings support the beneficial role of steroids on oxidative stress generally demonstrated by ascorbyl radical appearance. Reactive oxygen species decline is necessary for an upregulated production of reduced proteins.
引言
脑脊液分析可能有助于深入了解慢性炎症与治疗反应之间的相互作用。
目的
证明鞘内注射一次曲安奈德对慢性进行性多发性硬化症患者脑脊液中氧化还原电位和抗坏血酸自由基出现情况的影响。
方法
共有16名患者接受了40毫克曲安奈德治疗。电子自旋共振光谱法测量了添加铜离子[Cu(II)]后的氧化范围和抗坏血酸自由基的生物利用度。
结果
铜(II)离子吸收增加，这反映了还原蛋白含量的增加。根据文献，与健康对照相比，存在抗坏血酸自由基。
结论
鞘内应用类固醇会改变脑脊液中的氧化还原电位。我们的研究结果支持了类固醇对氧化应激的有益作用，这通常通过抗坏血酸自由基的出现来证明。活性氧的减少对于上调还原蛋白的产生是必要的。
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