Department of Neurology, Medical University in Lublin, Lublin, Poland.
Folia Neuropathol. 2010;48(2):116-22.
Multiple sclerosis (MS) patients were found to have elevated thiobarbituric acid reactive material levels, increased soluble sulfhydryl groups and reduced protein sulfhydryl groups in cerebrospinal fluid and serum, and slightly reduced superoxide dismutase in serum, which suggested disease activating free radical peroxidation. Moreover, levels of these varied across methylprednisolone (MP) therapy. We observed significant differences in the levels of peroxidation products between MS patients and controls. These changes were most evident in relapse. After MP therapy, levels of these indicators approached control values, especially in the remission period. Our findings suggest that MP protects against free radical attack.
多发性硬化症（MS）患者的脑脊液和血清中发现硫代巴比妥酸反应物质水平升高，可溶解巯基基团增加，蛋白质巯基基团减少，血清中超氧化物歧化酶略减少，这表明疾病激活了自由基过氧化。此外，这些水平在甲基强的松龙（MP）治疗中有所不同。我们观察到 MS 患者和对照组之间的过氧化产物水平存在显著差异。这些变化在复发时最为明显。MP 治疗后，这些指标的水平接近对照值，尤其是在缓解期。我们的发现表明 MP 可以防止自由基攻击。
