Tuzcu Kasım, Karcıoğlu Murat, Davarcı Işıl, Hakimoğlu Sedat, Akküçük Seçkin
Department of Anaesthesiology and Reanimation, Mustafa Kemal University Faculty of Medicine, Hatay, Turkey.
Department of General Surgery, Mustafa Kemal University Faculty of Medicine, Hatay, Turkey.
Turk J Anaesthesiol Reanim. 2014 Dec;42(6):348-51. doi: 10.5152/TJAR.2014.26214. Epub 2014 Jul 11.
Sickle cell disease (HbS) is a haemolytic anaemia characterized by the formation of abnormal haemoglobin. In patients with sickle cell disease, high rates of erythrocyte generation, degradation, and hyperbilirubinemia increase the risk for cholelithiasis. Previous studies have found that the incidence of cholelithiasis is 70% in adult patients. In sickle cell disease, decreased oxygen concentration leads to the sickling of erythrocytes by causing aggregation and polymerization. Sickle erythrocytes can have devastating effects on many vital organs by causing microvascular occlusion. In patients with sickle cell anaemia, anaesthetic technique, anaesthetic agents, and surgical trauma may cause additional risk. In this case report, we present a perioperative anaesthetic approach in the laparoscopic cholecystectomy of a patient with HbS, elevated liver function tests, and frequent pain crises.
镰状细胞病（HbS）是一种以异常血红蛋白形成为特征的溶血性贫血。在镰状细胞病患者中，红细胞生成、降解率高以及高胆红素血症增加了患胆石症的风险。先前的研究发现，成年患者胆石症的发病率为70%。在镰状细胞病中，氧浓度降低会通过引起聚集和聚合导致红细胞镰变。镰状红细胞可通过引起微血管阻塞对许多重要器官产生毁灭性影响。在镰状细胞贫血患者中，麻醉技术、麻醉剂和手术创伤可能会带来额外风险。在本病例报告中，我们介绍了一名患有镰状细胞病、肝功能检查结果升高且频繁发生疼痛危象的患者在腹腔镜胆囊切除术中的围手术期麻醉方法。
