Karaören Gülşah Yılmaz, Bakan Nurten, Yürük Cafer Tayyar, Çetinkaya Ali Osman
Clinic of Anaesthesiology and Reanimation, İstanbul Ümraniye Training and Research Hospital, İstanbul, Turkey.
Turk J Anaesthesiol Reanim. 2015 Apr;43(2):100-5. doi: 10.5152/TJAR.2014.57704. Epub 2015 Feb 5.
In Robot-assisted radical prostatectomy (RARP) patients, preoperative bowel preparation and intraoperative fluid restriction may cause dehydration and electrolyte imbalance. In these patients, laboratory results that are considered "normal" in the pre-anaesthesia clinic may be misleading, and cardiac arrhythmia due to hypokalaemia and hypocalcaemia, as well as problems, such as prolonged non-depolarising blockade and delayed recovery from anaesthesia, may be observed during anaesthesia practice. In this study, we aimed to determine these disturbances by comparing the preoperative (T1) laboratory values with those at the beginning of the operation (T2) and at the 6(th) hour of the operation (T3) and values at discharge.
This prospective study comprised 49 American Society of Anesthesiologists (ASA) I-II patients. Bowel preparation was made with a rectal enema (NaP) twice in 12 hours and with one single dose of oral laxative soda (NaP). During surgery, 1 mL kg(-1) h(-1) 0.09% NaCl and 1 mL kg(-1) h(-1) 6% HES 200/05 infusions were applied.
The potassium level at T2 was significantly lower than at T1 and T3. The calcium levels at T2 and T3 were significantly lower than at T1, and the level at T3 was significantly lower than at T2. The creatinine level at T3 was significantly higher than at T1 and T2.
Although there were no severe increases or decreases in laboratory test values due to bowel preparation and fluid restriction in RARP operations, which reflected on the clinical outcome in this ASA I-II patient group, these changes may be important in critically ill or ASA III-IV patients.
在机器人辅助根治性前列腺切除术(RARP)患者中,术前肠道准备和术中液体限制可能导致脱水和电解质失衡。在这些患者中,麻醉前门诊被认为“正常”的实验室检查结果可能会产生误导,并且在麻醉过程中可能会观察到因低钾血症和低钙血症导致的心律失常,以及诸如非去极化肌松阻滞延长和麻醉苏醒延迟等问题。在本研究中,我们旨在通过比较术前(T1)实验室值与手术开始时(T2)以及手术第6小时(T3)和出院时的值来确定这些紊乱情况。
这项前瞻性研究纳入了49例美国麻醉医师协会(ASA)I-II级患者。肠道准备采用在12小时内进行两次直肠灌肠(NaP)以及单次口服轻泻剂苏打(NaP)。手术期间,应用1 mL·kg⁻¹·h⁻¹的0.09%氯化钠和1 mL·kg⁻¹·h⁻¹的6%羟乙基淀粉200/05进行输注。
T2时的钾水平显著低于T1和T3。T2和T3时的钙水平显著低于T1,且T3时的水平显著低于T2。T3时的肌酐水平显著高于T1和T2。
尽管在RARP手术中,肠道准备和液体限制并未导致实验室检查值出现严重的升高或降低,这在该ASA I-II级患者组的临床结果中有所体现,但这些变化在危重症患者或ASA III-IV级患者中可能很重要。