Meço Başak Ceyda, Bermede Ahmet Onat, Alanoğlu Zekeriyya, Yaka Olcay, Alkış Neslihan
Department of Anaesthesiology and Reanimation, Ankara University School of Medicine, Ankara, Turkey.
Turk J Anaesthesiol Reanim. 2016 Feb;44(1):26-31. doi: 10.5152/TJAR.2016.05657. Epub 2016 Feb 1.
This prospective, randomized, double-blinded study aimed to compare the effects of three different doses of ketamine or lidocaine on intubating conditions and haemodynamics in a rapid-sequence induction model with 3 mg kg(-1) propofol and 0.6 mg kg(-1) rocuronium.
A total of 128 ASA I-III patients who were scheduled for elective surgery were randomized in the following five groups: Group 1 (n=24), 1 mg kg(-1) lidocaine+3 mg kg(-1) propofol+0.6 mg kg(-1) rocuronium; Group 2 (n=23), 0.1 mg kg(-1) ketamine+3 mg kg(-1) propofol+0.6 mg kg(-1) rocuronium; Group 3 (n=29), 0.3 mg kg(-1) ketamine+3 mg kg(-1) propofol+0.6 mg kg(-1) rocuronium; Group 4 (n=26), 0.5 mg kg(-1) ketamine+3 mg kg(-1) propofol+0.6 mg kg(-1) rocuronium and Group 5 (n=26), 3 mg kg(-1) propofol+0.6 mg kg(-1) rocuronium+saline as placebo. After preoxygenation, induction was performed with the assigned combination, and intubation was initiated after 60 s. The time to intubation, intubation score (Viby-Mogensen score) and haemodynamic data were recorded. Postoperative hoarseness, sore throat and hallucination incidences were followed up.
Demographic, time to intubation and haemodynamic data were comparable among groups. Group 4 [13.5 (4-14)] revealed a higher intubation score then groups 1, 2 and 5 [12 (3-14), 11 (2-14) and 9.5 (0-13) and p=0.026, p=0.001 and p=0.000001, respectively]. Groups 3 [13 (4-14)] and 4 [13.5 (4-14)] had similar intubation scores. Side effects were comparable among all groups.
The combination of 0.5 mg kg(-1) ketamine and 0.6 mg kg(-1) rocuronium along with propofol improves intubation conditions in a stimulated rapid-sequence induction model.
本前瞻性、随机、双盲研究旨在比较在使用3mg/kg丙泊酚和0.6mg/kg罗库溴铵的快速顺序诱导模型中，三种不同剂量的氯胺酮或利多卡因对插管条件和血流动力学的影响。
总共128例计划进行择期手术的美国麻醉医师协会（ASA）I-III级患者被随机分为以下五组：第1组（n=24），1mg/kg利多卡因+3mg/kg丙泊酚+0.6mg/kg罗库溴铵；第2组（n=23），0.1mg/kg氯胺酮+3mg/kg丙泊酚+0.6mg/kg罗库溴铵；第3组（n=29），0.3mg/kg氯胺酮+3mg/kg丙泊酚+0.6mg/kg罗库溴铵；第4组（n=26），0.5mg/kg氯胺酮+3mg/kg丙泊酚+0.6mg/kg罗库溴铵；第5组（n=26），3mg/kg丙泊酚+0.6mg/kg罗库溴铵+生理盐水作为安慰剂。预充氧后，用指定的组合进行诱导，并在60秒后开始插管。记录插管时间、插管评分（维比-莫根森评分）和血流动力学数据。对术后声音嘶哑、咽痛和幻觉的发生率进行随访。
各组间人口统计学、插管时间和血流动力学数据具有可比性。第4组[13.5（4-14）]的插管评分高于第1组、第2组和第5组[分别为12（3-14）、11（2-14）和9.5（0-13），p=0.026、p=0.001和p=0.000001]。第3组[13（4-14）]和第4组[1
