妊娠期外用皮质类固醇的安全性。
Safety of Topical Corticosteroids in Pregnancy.
机构信息
Department of Dermatology and Centre for Evidence-Based Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Chiayi, Taiwan.
Department of Dermatology, Far Eastern Memorial Hospital, New Taipei, Taiwan.
出版信息
JAMA Dermatol. 2016 Aug 1;152(8):934-5. doi: 10.1001/jamadermatol.2016.1009.
CLINICAL QUESTION
Are topical corticosteroids safe for use in pregnancy?
BOTTOM LINE
The available evidence found no associations of maternal use of topical corticosteroids of any potency with mode of delivery, birth defects, preterm delivery, fetal death, and low Apgar score. However, maternal use of potent to very potent topical corticosteroids, especially when the cumulative dosage of topical corticosteroids throughout the pregnancy is very large, is associated with low birth weight.
临床问题
局部皮质类固醇在妊娠期间使用安全吗？
结论
现有证据未发现任何强度的局部皮质类固醇药物的母体使用与分娩方式、出生缺陷、早产、胎儿死亡和低 Apgar 评分有关。然而，母体使用强效至超强效的局部皮质类固醇，特别是当整个怀孕期间局部皮质类固醇的累积剂量非常大时，与低出生体重有关。
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