Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China.
Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China.
Curr Opin Immunol. 2016 Oct;42:98-104. doi: 10.1016/j.coi.2016.06.009. Epub 2016 Jun 28.
Hepatitis C virus (HCV) infection tends persistent and causes chronic liver diseases, including inflammation, cirrhosis and hepatocellular carcinoma. Innate immune responses triggered by HCV infection, particularly the production of interferons and pro-inflammatory cytokines, shape the early host antiviral defense, and orchestrate subsequent HCV-specific adaptive immunity. Host has evolved multifaceted means to sense HCV infection to induce innate immune responses, whereas HCV has also developed elaborate strategies to evade immune attack. Recent studies in the field have provided many new insights into the interplay of HCV and innate immunity. In this review, we summarized these recent advances, focusing on pathogen recognition by innate sensors, newly discovered anti-HCV innate effectors and new viral strategies to evade innate immunity.
丙型肝炎病毒（HCV）感染往往持续存在，并导致慢性肝脏疾病，包括炎症、肝硬化和肝细胞癌。HCV 感染引发的固有免疫反应，特别是干扰素和促炎细胞因子的产生，塑造了早期宿主抗病毒防御，并协调随后的 HCV 特异性适应性免疫。宿主已经进化出多种感知 HCV 感染的方法来诱导固有免疫反应，而 HCV 也已经发展出精细的策略来逃避免疫攻击。该领域的最近研究为 HCV 和固有免疫之间的相互作用提供了许多新的见解。在这篇综述中，我们总结了这些最新进展，重点介绍了固有传感器的病原体识别、新发现的抗 HCV 固有效应物以及新的病毒逃避固有免疫的策略。
