J Biomed Opt. 2016 Jun 1;21(6):65008. doi: 10.1117/1.JBO.21.6.065008.
Although numerous studies have been performed to fabricate various optical tissue phantom (OTP) models, the fabrication of OTPs that simulate skin layers is laborious and time-consuming owing to the intricate characteristics of skin tissue. This study presents various OTP models that optically and structurally simulate the epidermis–dermis skin layer. The spin-coating method was employed to reproduce a uniform thin layer that mimics the epidermis layer, and the fabrication parameters were optimized for epoxy and silicone reference materials. Various OTP models simulating blood vessels and hyperpigmentation lesions were fabricated using the two reference materials to determine their feasibility. The suitability of each of the two reference materials for OTP fabrication was qualitatively evaluated by comparing the quality of the OTP models.
尽管已经进行了许多研究来制作各种光学组织体模（OTP）模型，但由于皮肤组织的复杂特性，制作模拟皮肤层的 OTP 仍然是一项费力且耗时的工作。本研究提出了各种光学上和结构上模拟表皮-真皮皮肤层的 OTP 模型。采用旋涂法来复制模仿表皮层的均匀薄层，并对环氧树脂和硅树脂参考材料的制造参数进行了优化。使用这两种参考材料来制作各种模拟血管和色素沉着病变的 OTP 模型，以确定它们的可行性。通过比较 OTP 模型的质量，定性地评估了这两种参考材料中每一种用于 OTP 制造的适用性。
