Mezuk Briana, Choi Moon, DeSantis Amy S, Rapp Stephen R, Diez Roux Ana V, Seeman Teresa
Department of Family Medicine and Population Health, Division of Epidemiology, Virginia Commonwealth University School of Medicine, Richmond, VA, United States of America.
Institute for Social Research, Ann Arbor, MI, United States of America.
PLoS One. 2016 Jul 1;11(7):e0158056. doi: 10.1371/journal.pone.0158056. eCollection 2016.
Both objective and subjective aspects of social isolation have been associated with alterations in immune markers relevant to multiple chronic diseases among older adults. However, these associations may be confounded by health status, and it is unclear whether these social factors are associated with immune functioning among relatively healthy adults. The goal of this study was to examine the associations between perceived loneliness and circulating levels of inflammatory markers among a diverse sample of adults.
Data come from a subset of the Multi-Ethnic Study of Atherosclerosis (n = 441). Loneliness was measured by three items derived from the UCLA Loneliness Scale. The association between loneliness and C-reactive protein (CRP) and fibrinogen was assessed using multivariable linear regression analyses. Models were adjusted for demographic and health characteristics.
Approximately 50% of participants reported that they hardly ever felt lonely and 17.2% felt highly lonely. Individuals who were unmarried/unpartnered or with higher depressive symptoms were more likely to report being highly lonely. There was no relationship between perceived loneliness and ln(CRP) (β = -0.051, p = 0.239) adjusting for demographic and health characteristics. Loneliness was inversely associated with ln(fibrinogen) (β = -0.091, p = 0.040), although the absolute magnitude of this relationship was small.
These results indicate that loneliness is not positively associated with fibrinogen or CRP among relatively healthy middle-aged adults.
社会隔离的客观和主观方面均与老年人多种慢性疾病相关的免疫标志物改变有关。然而，这些关联可能会受到健康状况的混淆，并且尚不清楚这些社会因素是否与相对健康的成年人的免疫功能有关。本研究的目的是在一个多样化的成年人样本中检验感知到的孤独感与炎症标志物循环水平之间的关联。
数据来自动脉粥样硬化多民族研究的一个子集（n = 441）。孤独感通过源自加州大学洛杉矶分校孤独量表的三个项目进行测量。使用多变量线性回归分析评估孤独感与C反应蛋白（CRP）和纤维蛋白原之间的关联。模型针对人口统计学和健康特征进行了调整。
约50%的参与者报告他们几乎从未感到孤独，17.2%的人感到非常孤独。未婚/无伴侣或抑郁症状较高的个体更有可能报告感到非常孤独。在调整人口统计学和健康特征后，感知到的孤独感与ln（CRP）之间没有关系（β = -0.051，p = 0.239）。孤独感与ln（纤维蛋白原）呈负相关（β = -0.09l，p = 0.040），尽管这种关系的绝对值很小。
这些结果表明，在相对健康的中年成年人中，孤独感与纤维蛋白原或CRP没有正相关。
