新型疾病-药物数据库展示了基于药物基因组学的处方适用性。
Novel Disease-Drug Database Demonstrating Applicability for Pharmacogenomic-Based Prescribing.
作者信息
Whirl-Carrillo M, Sangkuhl K, Gong L, Klein T E
机构信息
Department of Genetics, Stanford University, Stanford, California, USA.
出版信息
Clin Pharmacol Ther. 2016 Dec;100(6):600-602. doi: 10.1002/cpt.420. Epub 2016 Aug 13.
Abstract
Significant advances have been made in the clinical implementation of pharmacogenomics in recent years with tools for clinical decision support (CDS) being developed and integrated in the electronic health record (EHR). In this issue, the article by Hussain et al. describes the creation of a disease-drug association tool that enables providers to search by disease indications to receive a list of treatment options marked with pharmacogenomics annotations at the point of prescribing.
摘要
近年来，随着临床决策支持（CDS）工具的开发并集成到电子健康记录（EHR）中，药物基因组学在临床应用方面取得了重大进展。在本期中，侯赛因等人的文章描述了一种疾病-药物关联工具的创建，该工具使医疗服务提供者能够按疾病适应症进行搜索，以便在开处方时获得标记有药物基因组学注释的治疗选项列表。
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本文引用的文献
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Developing knowledge resources to support precision medicine: principles from the Clinical Pharmacogenetics Implementation Consortium (CPIC).开发知识资源以支持精准医学：来自临床药物基因组学实施联盟（CPIC）的原则
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The IGNITE network: a model for genomic medicine implementation and research.IGNITE网络：基因组医学实施与研究的一个模型。
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Pharmacogenomics in the clinic.临床中的药物基因组学。
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Preemptive clinical pharmacogenetics implementation: current programs in five US medical centers.前瞻性临床药物遗传学实施：美国五个医疗中心的当前项目
Annu Rev Pharmacol Toxicol. 2015;55:89-106. doi: 10.1146/annurev-pharmtox-010814-124835. Epub 2014 Oct 2.
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Clinical pharmacogenetics implementation: approaches, successes, and challenges.临床药物遗传学实施：方法、成果与挑战。
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Incorporation of pharmacogenomics into routine clinical practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline development process.将药物基因组学纳入常规临床实践：临床药物基因组学实施联盟（CPIC）指南制定过程。
Curr Drug Metab. 2014 Feb;15(2):209-17. doi: 10.2174/1389200215666140130124910.
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Development and use of active clinical decision support for preemptive pharmacogenomics.主动临床决策支持在预测性药物基因组学中的开发和应用。
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Institutional profile: University of Florida and Shands Hospital Personalized Medicine Program: clinical implementation of pharmacogenetics.机构简介：佛罗里达大学和 Shands 医院个性化医学计划：药物遗传学的临床实施。
Pharmacogenomics. 2013 May;14(7):723-6. doi: 10.2217/pgs.13.59.
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The 1200 patients project: creating a new medical model system for clinical implementation of pharmacogenomics.1200 例患者项目：创建一个新的医学模型系统，用于临床实施药物基因组学。
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CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network.CPIC：药物基因组学研究网络临床药物基因组学实施联盟。
Clin Pharmacol Ther. 2011 Mar;89(3):464-7. doi: 10.1038/clpt.2010.279. Epub 2011 Jan 26.
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