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新型疾病-药物数据库展示了基于药物基因组学的处方适用性。

Novel Disease-Drug Database Demonstrating Applicability for Pharmacogenomic-Based Prescribing.

作者信息

Whirl-Carrillo M, Sangkuhl K, Gong L, Klein T E

机构信息

Department of Genetics, Stanford University, Stanford, California, USA.

出版信息

Clin Pharmacol Ther. 2016 Dec;100(6):600-602. doi: 10.1002/cpt.420. Epub 2016 Aug 13.

DOI:10.1002/cpt.420
PMID:27367543
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5115984/
Abstract

Significant advances have been made in the clinical implementation of pharmacogenomics in recent years with tools for clinical decision support (CDS) being developed and integrated in the electronic health record (EHR). In this issue, the article by Hussain et al. describes the creation of a disease-drug association tool that enables providers to search by disease indications to receive a list of treatment options marked with pharmacogenomics annotations at the point of prescribing.

摘要

近年来,随着临床决策支持(CDS)工具的开发并集成到电子健康记录(EHR)中,药物基因组学在临床应用方面取得了重大进展。在本期中,侯赛因等人的文章描述了一种疾病-药物关联工具的创建,该工具使医疗服务提供者能够按疾病适应症进行搜索,以便在开处方时获得标记有药物基因组学注释的治疗选项列表。

相似文献

1
Novel Disease-Drug Database Demonstrating Applicability for Pharmacogenomic-Based Prescribing.新型疾病-药物数据库展示了基于药物基因组学的处方适用性。
Clin Pharmacol Ther. 2016 Dec;100(6):600-602. doi: 10.1002/cpt.420. Epub 2016 Aug 13.
2
Integrating pharmacogenomics into electronic health records with clinical decision support.将药物基因组学与临床决策支持系统整合到电子健康记录中。
Am J Health Syst Pharm. 2016 Dec 1;73(23):1967-1976. doi: 10.2146/ajhp160030.
3
Making pharmacogenomic-based prescribing alerts more effective: A scenario-based pilot study with physicians.提高基于药物基因组学的处方警示的有效性:一项针对医生的基于情景的试点研究。
J Biomed Inform. 2015 Jun;55:249-59. doi: 10.1016/j.jbi.2015.04.011. Epub 2015 May 7.
4
Incorporating Pharmacogenomics into Health Information Technology, Electronic Health Record and Decision Support System: An Overview.将药物基因组学纳入健康信息技术、电子健康记录和决策支持系统:概述
J Med Syst. 2017 Feb;41(2):19. doi: 10.1007/s10916-016-0673-4. Epub 2016 Dec 17.
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Disease-drug database for pharmacogenomic-based prescribing.基于药物基因组学的处方用药疾病-药物数据库。
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Implementation of Clinical Pharmacogenomics within a Large Health System: From Electronic Health Record Decision Support to Consultation Services.大型医疗系统中临床药物基因组学的实施:从电子健康记录决策支持到咨询服务
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PG4KDS: a model for the clinical implementation of pre-emptive pharmacogenetics.PG4KDS:一种用于抢先式药物遗传学临床应用的模型。
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Technical Challenges and Opportunities when Implementing Pharmacogenomics Decision Support Integrated in the Electronic Health Record.在电子健康记录中实施整合的药物基因组学决策支持时的技术挑战与机遇
Stud Health Technol Inform. 2017;245:1255.

本文引用的文献

1
Developing knowledge resources to support precision medicine: principles from the Clinical Pharmacogenetics Implementation Consortium (CPIC).开发知识资源以支持精准医学:来自临床药物基因组学实施联盟(CPIC)的原则
J Am Med Inform Assoc. 2016 Jul;23(4):796-801. doi: 10.1093/jamia/ocw027. Epub 2016 Mar 28.
2
The IGNITE network: a model for genomic medicine implementation and research.IGNITE网络:基因组医学实施与研究的一个模型。
BMC Med Genomics. 2016 Jan 5;9:1. doi: 10.1186/s12920-015-0162-5.
3
Pharmacogenomics in the clinic.临床中的药物基因组学。
Nature. 2015 Oct 15;526(7573):343-50. doi: 10.1038/nature15817.
4
Preemptive clinical pharmacogenetics implementation: current programs in five US medical centers.前瞻性临床药物遗传学实施:美国五个医疗中心的当前项目
Annu Rev Pharmacol Toxicol. 2015;55:89-106. doi: 10.1146/annurev-pharmtox-010814-124835. Epub 2014 Oct 2.
5
Clinical pharmacogenetics implementation: approaches, successes, and challenges.临床药物遗传学实施:方法、成果与挑战。
Am J Med Genet C Semin Med Genet. 2014 Mar;166C(1):56-67. doi: 10.1002/ajmg.c.31390. Epub 2014 Mar 10.
6
Incorporation of pharmacogenomics into routine clinical practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline development process.将药物基因组学纳入常规临床实践:临床药物基因组学实施联盟(CPIC)指南制定过程。
Curr Drug Metab. 2014 Feb;15(2):209-17. doi: 10.2174/1389200215666140130124910.
7
Development and use of active clinical decision support for preemptive pharmacogenomics.主动临床决策支持在预测性药物基因组学中的开发和应用。
J Am Med Inform Assoc. 2014 Feb;21(e1):e93-9. doi: 10.1136/amiajnl-2013-001993. Epub 2013 Aug 26.
8
Institutional profile: University of Florida and Shands Hospital Personalized Medicine Program: clinical implementation of pharmacogenetics.机构简介:佛罗里达大学和 Shands 医院个性化医学计划:药物遗传学的临床实施。
Pharmacogenomics. 2013 May;14(7):723-6. doi: 10.2217/pgs.13.59.
9
The 1200 patients project: creating a new medical model system for clinical implementation of pharmacogenomics.1200 例患者项目:创建一个新的医学模型系统,用于临床实施药物基因组学。
Clin Pharmacol Ther. 2012 Oct;92(4):446-9. doi: 10.1038/clpt.2012.117. Epub 2012 Aug 29.
10
CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network.CPIC:药物基因组学研究网络临床药物基因组学实施联盟。
Clin Pharmacol Ther. 2011 Mar;89(3):464-7. doi: 10.1038/clpt.2010.279. Epub 2011 Jan 26.