Li Fuqin, Duan Fujiao, Zhao Xia, Song Chunhua, Cui Shuli, Dai Liping
a Department of Hospital Infection Management , The First Affiliated Hospital of Zhengzhou University , Zhengzhou, Henan , China.
b Department of Nosocomial Infection Management , Affiliated Cancer Hospital of Zhengzhou University , Zhengzhou, Henan China.
Nutr Cancer. 2016 Aug-Sep;68(6):1034-43. doi: 10.1080/01635581.2016.1192200. Epub 2016 Jul 1.
The purpose of this study is to clarify and quantify the potential dose-response association between the intake of total red and total processed meat and risk of nasopharyngeal carcinoma (NPC). Relevant studies were identified by searching PubMed, EMBASE, and Chinese databases (CNKI and Wanfang). The summary relative risk (RR) with 95% confidence interval (95%CI) was calculated. A total of 15 independent studies with 12,735 subjects were identified. Compared with the low-rank intake, the summary RR of NPC was 1.35 (95%CI, 1.21-1.51) for total red meat and 1.46 (95%CI, 1.34-1.64) for total processed meat. For the moderate-rank intake, the summary RR of NPC was 1.54 (95%CI, 1.36-1.79) for total red meat and 1.59 (95%CI, 1.3-1.90) for total processed meat. The summary RR for high-rank intake was 1.71 (95%CI, 1.14-2.55) for total red meat and 2.11 (95%CI, 1.31-3.42) for total processed meat. The combined estimates showed obvious evidence of statistically significant association between total red and total processed meat consumption dose and risk of NPC (Ptrend< 0.01). In conclusion, our data suggest that a high intake of total red or total processed meat is associated with a significantly increased risk of NPC.
本研究的目的是阐明并量化总红肉和总加工肉类的摄入量与鼻咽癌（NPC）风险之间潜在的剂量反应关联。通过检索PubMed、EMBASE和中文数据库（CNKI和万方）来识别相关研究。计算了汇总相对风险（RR）及其95%置信区间（95%CI）。共识别出15项包含12,735名受试者的独立研究。与低摄入量相比，总红肉摄入导致NPC的汇总RR为1.35（95%CI，1.21 - 1.51），总加工肉类摄入导致NPC的汇总RR为1.46（95%CI，1.34 - 1.64）。对于中等摄入量，总红肉摄入导致NPC的汇总RR为1.54（95%CI，1.36 - 1.79），总加工肉类摄入导致NPC的汇总RR为1.59（95%CI，1.3 - 1.90）。高摄入量时，总红肉摄入导致NPC的汇总RR为1.71（95%CI，1.14 - 2.55），总加工肉类摄入导致NPC的汇总RR为2.11（95%CI，1.31 - 3.42）。合并估计显示，总红肉和总加工肉类的消费剂量与NPC风险之间存在统计学显著关联的明显证据（Ptrend < 0.01）。总之，我们的数据表明，高摄入总红肉或总加工肉类与NPC风险显著增加相关。
