甲基氧化偶氮甲醇诱导的小头畸形：皮质生长抑素样免疫反应性持续增加。

Methylazoxymethanol-induced microencephaly: persistent increase of cortical somatostatin-like immunoreactivity.

作者信息

Cattabeni F, Abbracchio M P, Cimino M, Cocchi D, Di Luca M, Mennuni L, Rosi F, Zaratin P

机构信息

Institute of Pharmacological Sciences, Milan, Italy.

出版信息

Brain Res Dev Brain Res. 1989 May 1;47(1):156-9. doi: 10.1016/0165-3806(89)90120-x.

DOI:10.1016/0165-3806(89)90120-x

PMID:2736763

Abstract

Treatment of pregnant rats with methylazoxymethanol (MAM) at day 15 of gestation induces a marked microencephaly in the offspring, characterized by impaired formation of interneurons in the areas affected. We have measured somatostatin immunoreactivity in the cortex, striatum and hippocampus of the offspring of pregnant rats treated with graded doses of MAM. A long-lasting increase in the cortical levels of this peptide was found, suggesting that somatostatinergic interneurons might be selectively spared by administration of the cytotoxic agent at this gestational age.

摘要

在妊娠第15天用甲基氧化偶氮甲醇（MAM）处理怀孕大鼠会导致后代出现明显的小头畸形，其特征是受影响区域的中间神经元形成受损。我们测量了用不同剂量MAM处理的怀孕大鼠后代的皮质、纹状体和海马体中的生长抑素免疫反应性。发现该肽的皮质水平持续升高，这表明在这个胎龄给予细胞毒性药物时，生长抑素能中间神经元可能被选择性地保留下来。