Akça Gökçen, Yerdelen Deniz, Balcı Mustafa Kemal, Uysal Hilmi
Akdeniz University Faculty of Medicine, Department of Neurology, Antalya, Turkey.
Başkent University Faculty of Medicine, Department of Neurology, Adana, Turkey.
Diabetes Res Clin Pract. 2016 Aug;118:112-20. doi: 10.1016/j.diabres.2016.04.058. Epub 2016 Jun 17.
We aimed to explore axonal excitability parameters in patients with diabetes mellitus (DM) and polyneuropathy (PNP) as well as those without PNP.
We used the short TROND protocol by QTRAC to measure axonal excitability parameters (strength-duration time constant (SDTC), rheobase, etc.) in 12 healthy subjects and 14 DM patients with PNP and 10 DM patients without PNP. The short TROND protocol was performed before and after 20min of deep hyperventilation in healthy subjects and patients with DM. Also, venous blood pH and partial pressure of O2 and CO2 were recorded before hyperventilation (HPV) and after 20min of HPV. A "hyperventilation score" was evaluated before and after HPV.
When the values of DM with PNP group and control group before HPV were compared, SDTC and latency were statistically significant. Comparing the values of the excitability parameters after HPV showed statistically significant changes in the SDTC, rheobase, and refractoriness at 2.5ms in controls and DM patients without PNP. HPV resulted in no changes in SDTC in DM patients with PNP.
The results of this study suggest that patients with DM and healthy subjects have different responses to HPV, and pH changes have different effects on diabetic PNP compared with healthy controls and DM patients without PNP.
我们旨在探究糖尿病（DM）合并多发性神经病（PNP）患者以及未患PNP的糖尿病患者的轴突兴奋性参数。
我们使用QTRAC的短TROND方案，测量12名健康受试者、14名患有PNP的糖尿病患者和10名未患PNP的糖尿病患者的轴突兴奋性参数（强度-时间常数（SDTC）、基强度等）。在健康受试者和糖尿病患者中，于深度过度通气20分钟前后进行短TROND方案。此外，在过度通气（HPV）前和HPV 20分钟后记录静脉血pH值以及氧气和二氧化碳分压。在HPV前后评估“过度通气评分”。
比较HPV前PNP合并糖尿病组与对照组的值，SDTC和潜伏期具有统计学意义。比较HPV后兴奋性参数的值，发现对照组和未患PNP的糖尿病患者的SDTC、基强度和2.5毫秒时的不应期有统计学意义的变化。HPV对患有PNP的糖尿病患者的SDTC无影响。
本研究结果表明，糖尿病患者与健康受试者对HPV的反应不同，与健康对照和未患PNP的糖尿病患者相比，pH变化对糖尿病性PNP有不同影响。
