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子宫内膜异位症的研究重点

Research Priorities for Endometriosis.

作者信息

Rogers Peter A W, Adamson G David, Al-Jefout Moamar, Becker Christian M, D'Hooghe Thomas M, Dunselman Gerard A J, Fazleabas Asgerally, Giudice Linda C, Horne Andrew W, Hull M Louise, Hummelshoj Lone, Missmer Stacey A, Montgomery Grant W, Stratton Pamela, Taylor Robert N, Rombauts Luk, Saunders Philippa T, Vincent Katy, Zondervan Krina T

机构信息

1 University of Melbourne, Melbourne, Australia.

2 Palo Alto Medical Foundation Fertility Physicians of Northern California, Palo Alto, CA, USA.

出版信息

Reprod Sci. 2017 Feb;24(2):202-226. doi: 10.1177/1933719116654991. Epub 2016 Sep 27.

DOI:10.1177/1933719116654991
PMID:27368878
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5933154/
Abstract

The 3rd International Consensus Workshop on Research Priorities in Endometriosis was held in São Paulo on May 4, 2014, following the 12th World Congress on Endometriosis. The workshop was attended by 60 participants from 19 countries and was divided into 5 main sessions covering pathogenesis/pathophysiology, symptoms, diagnosis/classification/prognosis, disease/symptom management, and research policy. This research priorities consensus statement builds on earlier efforts to develop research directions for endometriosis. Of the 56 research recommendations from the 2011 meeting in Montpellier, a total of 41 remained unchanged, 13 were updated, and 2 were deemed to be completed. Fifty-three new research recommendations were made at the 2014 meeting in Sao Paulo, which in addition to the 13 updated recommendations resulted in a total of 66 new recommendations for research. The research recommendations published herein, as well as those from the 2 previous papers from international consensus workshops, are an attempt to promote high-quality research in endometriosis by identifying and agreeing on key issues that require investigation. New areas included in the 2014 recommendations include infertility, patient stratification, and research in emerging nations, in addition to an increased focus on translational research. A revised and updated set of research priorities that builds on this document will be developed at the 13th World Congress on Endometriosis to be held on May 17-20, 2017, in Vancouver, British Columbia, Canada.

摘要

第三届子宫内膜异位症研究重点国际共识研讨会于2014年5月4日在圣保罗举行,紧随第十二届世界子宫内膜异位症大会之后。来自19个国家的60名参会者出席了此次研讨会,会议分为5个主要环节,涵盖发病机制/病理生理学、症状、诊断/分类/预后、疾病/症状管理以及研究政策。这份研究重点共识声明建立在早期为子宫内膜异位症制定研究方向的努力之上。在2011年蒙彼利埃会议提出的56项研究建议中,共有41项保持不变,13项得到更新,2项被认为已完成。2014年圣保罗会议提出了53项新的研究建议,加上13项更新的建议,总共产生了66项新的研究建议。本文发表的研究建议以及前两篇来自国际共识研讨会的论文中的建议,旨在通过确定并就需要调查的关键问题达成一致,推动子宫内膜异位症的高质量研究。2014年建议中包含的新领域除了更加关注转化研究外,还包括不孕症、患者分层以及新兴国家的研究。将于2017年5月17日至20日在加拿大不列颠哥伦比亚省温哥华举行的第十三届世界子宫内膜异位症大会将制定一套基于本文的修订和更新后的研究重点。

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本文引用的文献

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The influence of menstrual cycle and endometriosis on endometrial methylome.月经周期和子宫内膜异位症对子宫内膜甲基化组的影响。
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A systematic review on endometriosis during pregnancy: diagnosis, misdiagnosis, complications and outcomes.关于妊娠期子宫内膜异位症的系统评价:诊断、误诊、并发症和结局。
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Hepatocyte growth factor secreted by ovarian cancer cells stimulates peritoneal implantation via the mesothelial-mesenchymal transition of the peritoneum.卵巢癌细胞分泌的肝细胞生长因子通过腹膜间皮-间充质转化刺激腹膜种植。
Gynecol Oncol. 2015 Nov;139(2):345-54. doi: 10.1016/j.ygyno.2015.08.010. Epub 2015 Aug 31.
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Shared genetics underlying epidemiological association between endometriosis and ovarian cancer.子宫内膜异位症与卵巢癌之间流行病学关联背后的共同遗传学因素。
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Enhanced epithelial to mesenchymal transition (EMT) and upregulated MYC in ectopic lesions contribute independently to endometriosis.异位病灶中增强的上皮-间质转化(EMT)和上调的MYC各自独立地促进子宫内膜异位症。
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Improving Phenotypic Prediction by Combining Genetic and Epigenetic Associations.通过整合遗传和表观遗传关联改进表型预测
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Estradiol is a critical mediator of macrophage-nerve cross talk in peritoneal endometriosis.雌二醇是腹膜子宫内膜异位症中巨噬细胞与神经相互作用的关键介质。
Am J Pathol. 2015 Aug;185(8):2286-97. doi: 10.1016/j.ajpath.2015.04.012. Epub 2015 Jun 12.
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Effect of two laparoscopic techniques for treatment of ovarian endometrioma on ovarian reserve.两种腹腔镜技术治疗卵巢子宫内膜异位囊肿对卵巢储备功能的影响
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Association of chronic pelvic pain and endometriosis with signs of sensitization and myofascial pain.慢性盆腔疼痛和子宫内膜异位症与敏化迹象及肌筋膜疼痛的关联。
Obstet Gynecol. 2015 Mar;125(3):719-728. doi: 10.1097/AOG.0000000000000663.