Valadez-Cosmes Paulina, Vázquez-Martínez Edgar Ricardo, Cerbón Marco, Camacho-Arroyo Ignacio
Unidad de Investigación en Reproducción Humana, Instituto Nacional de Perinatología-Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.
Unidad de Investigación en Reproducción Humana, Instituto Nacional de Perinatología-Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.
Mol Cell Endocrinol. 2016 Oct 15;434:166-75. doi: 10.1016/j.mce.2016.06.027. Epub 2016 Jun 28.
Progesterone is a sexual steroid hormone that has a critical role in reproductive processes in males and females of several species, including humans. Furthermore, progesterone has been associated with pathological diseases such as breast, gynecological and brain cancer, regulating cell proliferation, apoptosis, and metastasis. In the past, progesterone actions were thought to be only mediated by its intracellular receptor (PR). However, recent evidence has demonstrated that membrane progesterone receptors (mPRs) mediate most of the non-classical progesterone actions. The role of the different mPRs subtypes in progesterone effects in reproduction and cancer is an emerging and exciting research area. Here we review studies to date regarding mPRs role in reproduction and cancer and discuss their functions and clinical relevance, suggesting mPRs as putative pharmacological targets and disease markers in cancer and diseases associated with reproduction.
孕酮是一种性甾体激素，在包括人类在内的多个物种的雄性和雌性生殖过程中发挥着关键作用。此外，孕酮与诸如乳腺癌、妇科癌症和脑癌等病理疾病相关，可调节细胞增殖、凋亡和转移。过去，人们认为孕酮的作用仅由其细胞内受体（PR）介导。然而，最近的证据表明，膜孕酮受体（mPRs）介导了大多数非经典的孕酮作用。不同mPRs亚型在孕酮对生殖和癌症影响中的作用是一个新兴且令人兴奋的研究领域。在此，我们综述了迄今为止关于mPRs在生殖和癌症中作用的研究，并讨论了它们的功能和临床相关性，表明mPRs可作为癌症以及与生殖相关疾病的潜在药理学靶点和疾病标志物。
