Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas.
Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands.
Clin Infect Dis. 2016 Oct 1;63(7):944-8. doi: 10.1093/cid/ciw445. Epub 2016 Jul 1.
The probe-to-bone (PTB) test is a commonly used clinical test for osteomyelitis (OM), but its utility has been questioned in clinical settings where the prevalence of OM is low. This article aims to systematically review the accuracy of the PTB test to diagnose diabetic foot OM. We searched Ovid Medline and Scopus databases for studies using the keywords "probe to bone," "osteomyelitis," and "diabetic foot" from 1946 to May 2015. We summarized characteristics of the included studies and pooled the accuracy numbers using a bivariate random-effects model. Seven studies met our inclusion criteria. Pooled sensitivity and specificity for the PTB test was 0.87 (95% confidence interval [CI], .75-.93) and 0.83 (95% CI, .65-.93), respectively. We conclude that the PTB test can accurately rule in diabetic foot OM in the high-risk patients and rule out OM in low-risk patients.
探针至骨（PTB）试验是一种常用于骨髓炎（OM）的临床检测方法，但在 OM 发病率低的临床环境中，其效用受到质疑。本文旨在系统地回顾 PTB 试验诊断糖尿病足 OM 的准确性。我们通过关键词“探针至骨”、“骨髓炎”和“糖尿病足”在 Ovid Medline 和 Scopus 数据库中搜索了 1946 年至 2015 年 5 月的研究。我们总结了纳入研究的特征，并使用双变量随机效应模型汇总了准确性数据。有 7 项研究符合纳入标准。PTB 试验的汇总敏感性和特异性分别为 0.87（95%置信区间[CI]，0.75-0.93）和 0.83（95% CI，0.65-0.93）。我们的结论是，PTB 试验可以准确地在高危患者中确定糖尿病足 OM，并在低危患者中排除 OM。
