Nosál'ová G, Strapková A, Korpás J, Criscuolo D
Department of Pathophysiology and Pharmacology, Medical Faculty, Comenius University, Martin, Czechoslovakia.
Drugs Exp Clin Res. 1989;15(2):77-81.
The influences of the antitussive activity of glaucine were studied in 56 non-anaesthetized cats under normal and pathological conditions. Cough was induced by mechanical stimulation of the airways with a nylon fibre. The authors found that if glaucine was administered at a dose of 5.0, 7.5 and 10.0 mg/kg b.w., i.p., it evoked statistically significant suppression on single cough components. After inflammation of the airways was induced with unsoluted croton oil, no decrease in antitussive activity of glaucine could be observed, according to the number of cough efforts, frequency, intensity of maximal cough effort, and intensity of cough attack during expiration. Glaucine used under such conditions was not found to be powerful enough to suppress either the intensity of maximal cough effort or the intensity of cough attack during inspiration. The antitussive effect of glaucine was stronger under pathological conditions (Staphylococcus-induced inflammation). The antitussive effect of glaucine was approximately the same as with codeine if administered in equal doses.
在56只正常和病理状态下的未麻醉猫身上研究了青藤碱的镇咳活性影响。用尼龙纤维机械刺激气道诱发咳嗽。作者发现，腹腔注射青藤碱剂量为5.0、7.5和10.0mg/kg体重时，对单次咳嗽成分有统计学上显著的抑制作用。在用未稀释的巴豆油诱发气道炎症后，根据咳嗽次数、频率、最大咳嗽努力强度和呼气时咳嗽发作强度，未观察到青藤碱镇咳活性降低。在这种情况下使用的青藤碱不足以抑制最大咳嗽努力强度或吸气时咳嗽发作强度。青藤碱在病理状态（葡萄球菌诱导的炎症）下的镇咳作用更强。如果给予相同剂量，青藤碱的镇咳作用与可待因大致相同。
