Franova S, Nosalova G
Department of Pharmacology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia.
Bratisl Lek Listy. 2004;105(5-6):203-6.
Cough is the most important defence reflex of the airways. Little information exists about participation of the ion channels in the mechanism of the cough reflex.
The aim of the study was to investigate the effect of diltiazem administration on the sensitivity of the mechanically induced cough reflex in experimental conditions.
Mechanical stimulation of the laryngopharyngeal and tracheobronchial area of the airways in non-anaesthetized cats was used in this experiment. The number of cough efforts, and the frequency and intensity of the cough attack were utilized as evaluated parameters.
Perorally administered diltiazem (30 mg/kg b.w.) caused a statistically significant decrease of measured cough parameters. Cough - suppressing activity of diltiazem was lower than codeine, but higher than dropropizine and prenoxdiazine.
Experimental results showed antitussive activity of the calcium-channel blocker diltiazem and suggested the role of voltage-gated calcium channels of type L in mechanism of the cough reflex. (Fig. 4, Ref. 15.).
咳嗽是气道最重要的防御反射。关于离子通道在咳嗽反射机制中的参与情况，现有信息较少。
本研究旨在探讨在实验条件下给予地尔硫䓬对机械诱导咳嗽反射敏感性的影响。
本实验采用对未麻醉猫的喉咽和气管支气管区域进行机械刺激。将咳嗽次数、咳嗽发作频率和强度作为评估参数。
口服地尔硫䓬（30毫克/千克体重）使测量的咳嗽参数有统计学意义的下降。地尔硫䓬的镇咳活性低于可待因，但高于右丙氧芬和氯氮䓬。
实验结果显示钙通道阻滞剂地尔硫䓬具有镇咳活性，并提示L型电压门控钙通道在咳嗽反射机制中的作用。（图4，参考文献15。）
