Shelby M D, Gulati D K, Tice R R, Wojciechowski J P
Cellular and Genetic Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.
Environ Mol Mutagen. 1989;13(4):339-42. doi: 10.1002/em.2850130410.
Three human carcinogens, 4-aminobiphenyl, treosulphan, and melphalan, were tested for the induction of micronuclei or chromosomal aberrations in the bone marrow cells of male B6C3F1 mice. These studies were conducted to provide further information on the in vivo genetic toxicity of compounds known to cause cancer in humans. All three compounds gave positive results in the mouse bone marrow micronucleus test, and melphalan, the only compound tested for aberration induction, was positive in this assay. These results extend the evidence that nearly all known human carcinogens are detected in relatively simple and widely employed short-term in vivo tests.
对三种人类致癌物4-氨基联苯、苏消安和美法仑进行了测试，以观察其对雄性B6C3F1小鼠骨髓细胞微核或染色体畸变的诱导作用。开展这些研究是为了提供更多关于已知可导致人类癌症的化合物的体内遗传毒性信息。所有这三种化合物在小鼠骨髓微核试验中均给出阳性结果，而美法仑是唯一进行了畸变诱导测试的化合物，在该试验中呈阳性。这些结果进一步证明，几乎所有已知的人类致癌物都能在相对简单且广泛应用的短期体内试验中被检测出来。
