Qu Zhao, Zheng Na, Zhang Yifan, Zhang Li, Liu Jianghong, Wang Qi, Yin Linlin
a Xuan Wu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education , Beijing Geriatric Medical Research Center, Beijing Institute for Brain Disorders , Beijing , P.R. China.
b Institute of Clinical Pharmacology , Guangzhou University of Chinese Medicine , Guangzhou , P.R. China.
Neurol Res. 2016 Sep;38(9):831-7. doi: 10.1080/01616412.2016.1200766. Epub 2016 Jul 4.
The present study was designed to investigate the beneficial effects of cornel iridoid glycoside (CIG), a main component extract from Cornus officinalis, on neurotrophin expression in mouse experimental autoimmune encephalomyelitis (EAE), a classical model of multiple sclerosis (MS). After EAE initiation, CIG was intragastrically administered daily for 32 days and reduced disease severity. Histopathological staining and western blotting both showed that CIG could prevent brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) loss in the spinal cord of EAE mice. In conclusion, our findings indicated that CIG treatment suppressed disease severity of EAE partially through blocking downregulation of neurotrophic factor expression such as BDNF and NGF, suggesting that CIG may have beneficial effects for the treatment of demyelinating diseases such as MS.
本研究旨在探讨山茱萸环烯醚萜苷（CIG）（山茱萸的主要成分提取物）对实验性自身免疫性脑脊髓炎（EAE）小鼠神经营养因子表达的有益作用，EAE是多发性硬化症（MS）的经典模型。在EAE发病后，每天经胃内给予CIG，持续32天，可减轻疾病严重程度。组织病理学染色和蛋白质印迹均显示，CIG可防止EAE小鼠脊髓中脑源性神经营养因子（BDNF）和神经生长因子（NGF）的丢失。总之，我们的研究结果表明，CIG治疗可部分通过阻止BDNF和NGF等神经营养因子表达的下调来抑制EAE的疾病严重程度，这表明CIG可能对治疗MS等脱髓鞘疾病具有有益作用。
