Mifflin Katherine A, Frieser Emma, Benson Curtis, Baker Glen, Kerr Bradley J
Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada.
Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada; Department of Psychiatry (NRU), University of Alberta, Edmonton, AB T6G 2G3, Canada.
J Neuroimmunol. 2017 Apr 15;305:135-144. doi: 10.1016/j.jneuroim.2017.02.005. Epub 2017 Feb 11.
Multiple sclerosis (MS) is an inflammatory neurodegenerative disease of the central nervous system. The primary symptoms of MS include the loss of sensory and motor function. Exercise has been shown to modulate disease parameters in experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, by reducing immune cell infiltration and oxidative stress. However, these initial studies were carried out exclusively in female mice. The present study compared the effects of daily voluntary wheel running on several disease parameters in male and female mice with EAE. Male and female mice were given access to a running wheel for 1h a day for 30 consecutive days. Daily wheel running significantly improved clinical scores in males with EAE but had little effect on clinical signs in females with the disease. Direct comparison of inflammation, axonal injury, and oxidative stress in male and female mice with EAE revealed significant differences in the amount of T-cell infiltration, microglia reactivity, demyelination and axon integrity. Male mice with EAE given daily access to running wheels also had significantly less ongoing oxidative stress compared to all other groups. Taken together, our results indicate that the inflammatory response generated in EAE is distinct between the sexes and its modulation by daily exercise can have sex-specific effects on disease-related outcomes.
多发性硬化症（MS）是一种中枢神经系统的炎性神经退行性疾病。MS的主要症状包括感觉和运动功能丧失。在实验性自身免疫性脑脊髓炎（EAE，一种MS的小鼠模型）中，运动已被证明可通过减少免疫细胞浸润和氧化应激来调节疾病参数。然而，这些初步研究仅在雌性小鼠中进行。本研究比较了每日自愿轮转运动对雄性和雌性EAE小鼠几种疾病参数的影响。雄性和雌性小鼠连续30天每天有1小时使用转轮的机会。每日轮转运动显著改善了雄性EAE小鼠的临床评分，但对患有该疾病的雌性小鼠的临床症状影响不大。对雄性和雌性EAE小鼠的炎症、轴突损伤和氧化应激进行直接比较，发现T细胞浸润量、小胶质细胞反应性、脱髓鞘和轴突完整性存在显著差异。与所有其他组相比，每天有机会使用转轮的雄性EAE小鼠的持续氧化应激也显著较少。综上所述，我们的结果表明，EAE中产生的炎症反应在性别之间是不同的，并且日常运动对其调节可能会对疾病相关结果产生性别特异性影响。
