Lattanzi Simona, Silvestrini Mauro, Provinciali Leandro
Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy.
Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy.
Neurol Neurochir Pol. 2016 Jul-Aug;50(4):271-4. doi: 10.1016/j.pjnns.2016.03.001. Epub 2016 Mar 15.
The cortical laminar necrosis (CLN) is a permanent injury characterized by the selective delayed necrosis of the cerebral cortex, mainly of the third layer, and usually greater in the depths and sides of the sulci than over the crest of the gyri. The damage involves all cellular components - either neurons, glia cells and blood vessels - and results in a focal cortical band of pan-necrosis detectable in late sub-acute or chronic stages of reduced energy supply to the brain. The CLN has been described in different conditions as hypoxia, hypoglycemia and status epilepticus. At brain CT or MR scans it appears with pathognomonic highly hyperdense or T1-hyperintense lesions following the gyral anatomy of the cerebral cortex. We reported a case of CLN associated to myocardial infarct and discussed the underlying mechanisms.
皮质层状坏死（CLN）是一种永久性损伤，其特征为大脑皮质，主要是第三层，出现选择性延迟坏死，通常在脑沟深处和两侧比脑回顶部更严重。损伤累及所有细胞成分——神经元、胶质细胞和血管——并导致在大脑能量供应减少的亚急性晚期或慢性阶段可检测到的局灶性皮质全层坏死带。CLN已在缺氧、低血糖和癫痫持续状态等不同情况下被描述。在脑部CT或磁共振扫描中，它表现为符合大脑皮质脑回解剖结构的特征性高密度或T1高信号病变。我们报告了一例与心肌梗死相关的CLN病例，并讨论了潜在机制。
