Barnea E R, Perlman R, Bick T, Hochberg Z
Feto-Placental Endocrinology Unit, Rappaport Family Institute for Research in the Medical Sciences, Technion Haifa, Israel.
Gynecol Obstet Invest. 1989;27(3):133-6. doi: 10.1159/000293640.
The role of human growth hormone (hGH) on placental hormone secretion at term was investigated in two in vitro models: placental explants and cultured trophoblastic cells. Physiological concentrations of hGH caused a significant dose-dependent increase in placental lactogen and progesterone secretion. In the explant model it stimulated estradiol secretion. In order to determine whether this stimulatory effect on estradiol is exerted via aromatase, an isolated cell culture was utilized where androstenedione was supplied as substrate. In this model, hGH exerted a mild inhibitory effect. In conclusion, hGH at levels present in the fetal circulation exerts a significant stimulatory effect upon placental function as reflected by both peptide and steroid hormone production and secretion. The effect of estradiol secretion is the end result of an inhibitory effect on androgen aromatization and a stimulatory effect on earlier steps.
在两个体外模型（胎盘外植体和培养的滋养层细胞）中研究了人生长激素（hGH）对足月胎盘激素分泌的作用。生理浓度的hGH导致胎盘催乳素和孕酮分泌显著的剂量依赖性增加。在外植体模型中，它刺激了雌二醇分泌。为了确定这种对雌二醇的刺激作用是否通过芳香化酶发挥，使用了一种分离细胞培养物，其中以雄烯二酮作为底物。在该模型中，hGH发挥了轻微的抑制作用。总之，胎儿循环中存在的hGH水平对胎盘功能发挥了显著的刺激作用，这体现在肽类和类固醇激素的产生和分泌上。雌二醇分泌的影响是对雄激素芳香化的抑制作用和对早期步骤的刺激作用的最终结果。
